Table 4 The significant terms identified by GO enrichment analysis for the upregulated DEGs in necrosis of the femoral head samples (p<0.05)

BP

GO:0019882

Antigen processing and presentation

5

0.000006999

HLA-DRB5, HLA-DMB, CTSH, HLA-DRB3, HLA-DRB1

GO:0002504

Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

4

0.000007113

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

GO:0006968

Cellular defense response

5

0.000011319

TYROBP, NCF1, NCF2, CXCR2, MNDA

GO:0002381

Immunoglobulin production involved in immunoglobulin mediated immune response

3

0.000049653

HLA-DRB5, HLA-DRB1, GAPT

GO:0019886

Antigen processing and presentation of exogenous peptide antigen via MHC class II

5

0.000054005

HLA-DRB5, HLA-DMB, IFI30, HLA-DRB3, HLA-DRB1

GO:0060333

Interferon-gamma-mediated signaling pathway

4

0.000549531

HLA-DRB5, IFI30, HLA-DRB3, HLA-DRB1

GO:0007165

Signal transduction

10

0.000916089

CSF3R, TYROBP, CXCR2, FPR1, RARA, ARAP1, STK4, HLA-DRB3, ...

GO:0006954

Inflammatory response

6

0.001551430

CXCR1, CXCR2, FPR1, CHI3L1, FPR2, AIF1

GO:0032689

Negative regulation of interferon-gamma production

3

0.001816240

HLA-DRB5, RARA, HLA-DRB1

GO:0006935

Chemotaxis

4

0.002622088

CXCR1, CXCR2, FPR1, FPR2

CC

GO:0042613

MHC class II protein complex

4

0.000013567

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

GO:0030666

Endocytic vesicle membrane

4

0.000377723

CD163, HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0005887

Integral component of plasma membrane

11

0.000608833

CD163, ENTPD1, CSF3R, TYROBP, CXCR2, FPR1, LPAR2, FPR2, ...

GO:0031902

Late endosome membrane

4

0.001306338

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

GO:0071556

Integral component of luminal side of endoplasmic reticulum membrane

3

0.001746841

HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0030658

Transport vesicle membrane

3

0.002988198

HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0030669

Clathrin-coated endocytic vesicle membrane

3

0.003471454

HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0012507

ER to Golgi transport vesicle membrane

3

0.005531042

HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0005886

Plasma membrane

17

0.007697000

CD163, HLA-DRB5, ENTPD1, CSF3R, FPR1, LPAR2, LILRA1, FPR2, ...

GO:0032010

Phagolysosome

2

0.008533401

NCF1, NCF2

MF

GO:0042605

Peptide antigen binding

3

0.001704631

HLA-DRB5, HLA-DRB3, HLA-DRB1

GO:0004918

Interleukin-8 receptor activity

2

0.004378952

CXCR1, CXCR2

GO:0019959

Interleukin-8 binding

2

0.006561426

CXCR1, CXCR2

GO:0004982

N-formyl peptide receptor activity

2

0.008739245

FPR1, FPR2

GO:0004875

Complement receptor activity

2

0.013080956

FPR1, FPR2

GO:0016175

Superoxide-generating NADPH oxidase activity

2

0.023854442

NCF1, NCF2

GO:0032395

MHC class II receptor activity

2

0.032390762

HLA-DRB3, HLA-DRB1

GO:0023026

MHC class II protein complex binding

2

0.034513467

HLA-DMB, HLA-DRB1

GO:0004709

MAP kinase activity

2

0.047154872

MAP3K7CL, MAP3K5