Skip to main content

Table 2 Mean values (±standard deviation) of different parameters evaluated at the initial evaluation and throughout the study

From: RETRACTED ARTICLE: Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial

Modality

Treatment day

8 days

15 days

CG

HG

CG

HG

p

CG

HG

p

Mean

SD

Mean

SD

Mean

SD

Mean

SD

Mean

SD

Mean

SD

 Goniometry

Flexion (°, mean±SD)

55.0

4.4

54.9

4.1

55.3

3.7

55.9

3.8

0.1

57.2

5.2

58.6

4.7

0.3

Extension (°, mean±SD)

151.2

3.9

149.8

8.6

149.9

4.6

149.8

8.6

1.00

151.1

3.5

150.2

5.5

 

Thigh girth (cm, mean±SD)

31.2

2.6

30.4

3.3

31.1

3.3

29.3

2.8

1.0

31.1

2.9

31.3

3.2

1.0

Pedometer (daily steps±SD)

1445.7

755.7

1107.0

998.8

829.5

931.3

782.0

842.9

1.0

606.0

309.5

845.0

472.0

1.0

 CMI

HVAS (0–10)

6.8

1.2

6.6

1.4

6.7

1.5

6.7

1.3

1.0

6.8

1.2

6.8

1.4

1.0

CBPI—PSS (0–10)

3.1

1.9

3.3

2.6

3.4

2.3

2.8

1.5

0.04*

3.7

2.8

2.6

1.6

0.04*

CBPI—PIS (0–10)

3.2

2.2

3.4

2.3

3.4

2.1

3.2

1.9

0.02*

3.6

2.1

3.3

2.7

0.02*

COI—Stiffness (0–16)

3.4

3.4

17.0

10.5

4.1

3.3

4.2

3.2

0.88

4.1

3.2

3.8

2.6

0.38

COI—Function (0–16)

3.6

4.1

3.4

2.9

4.1

4.0

4.4

3.2

0.06

4.4

5.5

4.3

3.2

0.37

COI—Gait (0–20)

4.7

5.2

4.6

3.5

5.4

6.1

6.6

4.2

0.46

5.8

4.3

7.0

4.3

0.86

COI—QOL (0–12)

4.5

2.6

7.4

4.7

4.6

2.7

4.4

2.5

0.40

4.7

2.9

4.4

2.2

0.22

COI—Overall score (0–64)

16.4

14.7

4.5

3.1

18.2

13.8

19.7

12.0

0.75

18.6

13.8

19.6

11.1

0.19

LOAD (0–52)

13.6

10.5

19.9

12.7

14.4

12.7

16.2

9.4

0.73

14.3

10.7

16.6

9.4

0.18

 Digital thermography

DV (°, mean±SD)

24.7

1.9

25.8

1.4

25.2

1.3

24.9

1.3

0.02*

24.4

1.6

24.4

1.5

1.0

DV max (°, mean±SD)

26.3

1.9

26.6

1.6

25.8

1.0

26.2

1.2

1.0

26.7

1.6

25.8

1.4

1.0

Lt (°, mean±SD)

28.7

2.7

26.9

2.1

31.6

2.1

31.6

2.6

<0.01*

29.7

2.9

30.8

2.5

<0.01*

Lt max (°, mean±SD)

31.9

3.1

30.4

3.3

34.9

1.0

33.8

2.8

<0.01*

34.9

0.8

34.3

0.7

<0.01*

 Synovial fluid

IL-1 (pg/mL, mean±SD)

170.9

120.4

182.4

157.4

72.3

42.4

141.2

138.1

0.01*

-

-

-

-

-

CRP (mg/mL, mean±SD)

0.4

1.0

0.2

0.3

0.3

1.2

0.2

0.0

0.2

-

-

-

-

-

 Weight bearing

Symmetry index (mean±SD)

24.7

20.3

21.7

24.9

18.7

17.1

36.4

37.5

<0.01*

23.9

16.3

23.9

23.7

0.4

Deviation (mean±SD)

2.8

3.6

3.8

3.5

2.78

1.987

4.1

3.6

1.0

2.94

2.127

2.5

2.7

1.0

Modality

30 days

90 days

180 days

CG

HG

p

CG

HG

p

CG

HG

p

mean

SD

mean

SD

mean

SD

mean

SD

mean

SD

mean

SD

 Goniometry

Flexion (°, mean±SD)

53.6

2.9

56.3

4.5

1.0

52.7

2.9

51.7

2.6

0.03*

51.6

2.2

49.1

5.0

<0.01*

Extension (°, mean±SD)

150.8

3.4

152.0

6.0

 

150.8

2.9

152.0

4.7

 

151.3

2.9

150.7

11.5

 

Thigh girth (cm, mean±SD)

30.6

2.7

29.3

2.2

0.4

31.6

2.7

31.1

5.5

1.0

31.5

2.2

31.6

4.2

1.0

Pedometer (daily steps±SD)

594.5

663.4

760.0

292.0

1.0

451.9

463.0

635.0

43.0

1.0

434.9

455.8

652.0

90.9

1.0

CMI

HVAS (0–10)

6.4

1.4

6.9

1.5

0.56

6.6

1.7

6.5

1.2

0.85

6.5

1.4

6.5

1.6

0.61

CBPI—PSS (0-10)

3.7

2.6

3.0

2.6

<0.05*

4.1

2.9

2.9

2.1

0.04*

3.6

3.1

2.9

2.4

0.04*

CBPI—PIS (0-10)

3.8

2.6

3.2

2.7

0.02*

3.9

2.8

3.2

2.7

0.03*

3.5

2.4

3.2

2.7

<0.05*

COI—Stiffness (0–16)

4.6

4.1

3.5

3.8

0.11

4.6

3.9

4.0

4.0

0.49

4.0

5.7

4.3

4.3

0.81

COI—Function (0–16)

5.7

5.3

4.3

3.9

0.02*

5.0

5.2

4.1

4.1

0.02*

4.0

5.4

3.3

3.8

<0.05*

COI—Gait (0–20)

6.9

5.1

5.2

5.1

0.03*

5.7

5.5

5.0

4.9

<0.05*

4.4

5.4

6.1

5.8

0.36

COI—QOL (0–12)

5.3

3.3

4.0

2.4

0.11

5.1

2.8

4.4

2.7

0.84

4.7

2.6

4.2

2.9

0.79

COI—Overall score (0–64)

22.4

19.1

5.2

5.1

<0.01*

20.1

15.7

5.0

4.9

0.01*

15.7

14.9

19.7

17.3

0.59

LOAD (0–52)

16.4

13.1

15.0

9.7

0.09

13.1

12.4

15.3

10.8

0.56

13.1

12.4

16.4

11.8

0.99

Digital termography

DV (°, mean±SD)

25.3

1.5

26.3

2.2

1.0

26.1

1.2

26.5

0.9

0.7

25.6

1.4

25.6

26.0

1.0

DV max (°, mean±SD)

25.2

2.1

27.6

2.0

<0.05*

27.4

1.4

27.5

1.2

0.2

26.9

1.4

27.4

0.9

0.3

Lt (°, mean±SD)

29.8

2.2

31.6

1.8

<0.01*

28.4

1.8

29.9

1.7

<0.01*

27.3

1.8

29.9

1.7

<0.01*

Lt max (°, mean±SD)

33.9

1.2

34.6

0.7

<0.01*

30.5

1.9

31.8

1.7

<0.01*

29.7

1.9

30.9

2.0

<0.01*

Synovial fluid

IL-1 (pg/mL, mean±SD)

122.9

108.9

124.2

86.9

0.2

159.6

59.1

159.6

59.1

0.6

184.2

68.5

152.3

83.7

1.0

CRP (mg/mL, mean±SD)

0.48

0.9

0.3

0.1

0.2

0.4

0.8

0.4

0.2

0.1

0.0

0.0

0.3

0.2

1.0

Weight bearing

Symmetry index (mean±SD)

18.9

12.2

14.5

15.0

<0.01*

27.4

12.1

7.6

7.5

<0.05*

27.0

27.9

5.2

3.9

0.01*

Deviation (mean±SD)

2.5

1.9

1.9

1.8

<0.01*

2.72

2.27

1.3

1.3

<0.05*

2.61

2.973

2.6

2.9

0.01*

  1. CBPI, Canine Brief Pain Inventory; CRP, C-reactive protein; COI, Canine Orthopedic Index; DV, dorsoventral view; HVAS, Hudson Visual Analogue Scale; IL-1, interleukin 1; LOAD, Liverpool Osteoarthritis in Dogs; LT, lateral view; PIS, Pain Interference Score; PSS, Pain Severity Score; QOL, quality of life
  2. *Significance when comparing the value registered by a group at an evaluation moment with T0, and comparing both group at each follow-up moment
Back to article page

Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X