Skip to main content

Table 2 Mean values (±standard deviation) of different parameters evaluated at the initial evaluation and throughout the study

From: Effect of a single intra-articular high molecular weight hyaluronan in a naturally occurring canine osteoarthritis model: a randomized controlled trial

Modality Treatment day 8 days 15 days
CG HG CG HG p CG HG p
Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD
 Goniometry Flexion (°, mean±SD) 55.0 4.4 54.9 4.1 55.3 3.7 55.9 3.8 0.1 57.2 5.2 58.6 4.7 0.3
Extension (°, mean±SD) 151.2 3.9 149.8 8.6 149.9 4.6 149.8 8.6 1.00 151.1 3.5 150.2 5.5  
Thigh girth (cm, mean±SD) 31.2 2.6 30.4 3.3 31.1 3.3 29.3 2.8 1.0 31.1 2.9 31.3 3.2 1.0
Pedometer (daily steps±SD) 1445.7 755.7 1107.0 998.8 829.5 931.3 782.0 842.9 1.0 606.0 309.5 845.0 472.0 1.0
 CMI HVAS (0–10) 6.8 1.2 6.6 1.4 6.7 1.5 6.7 1.3 1.0 6.8 1.2 6.8 1.4 1.0
CBPI—PSS (0–10) 3.1 1.9 3.3 2.6 3.4 2.3 2.8 1.5 0.04* 3.7 2.8 2.6 1.6 0.04*
CBPI—PIS (0–10) 3.2 2.2 3.4 2.3 3.4 2.1 3.2 1.9 0.02* 3.6 2.1 3.3 2.7 0.02*
COI—Stiffness (0–16) 3.4 3.4 17.0 10.5 4.1 3.3 4.2 3.2 0.88 4.1 3.2 3.8 2.6 0.38
COI—Function (0–16) 3.6 4.1 3.4 2.9 4.1 4.0 4.4 3.2 0.06 4.4 5.5 4.3 3.2 0.37
COI—Gait (0–20) 4.7 5.2 4.6 3.5 5.4 6.1 6.6 4.2 0.46 5.8 4.3 7.0 4.3 0.86
COI—QOL (0–12) 4.5 2.6 7.4 4.7 4.6 2.7 4.4 2.5 0.40 4.7 2.9 4.4 2.2 0.22
COI—Overall score (0–64) 16.4 14.7 4.5 3.1 18.2 13.8 19.7 12.0 0.75 18.6 13.8 19.6 11.1 0.19
LOAD (0–52) 13.6 10.5 19.9 12.7 14.4 12.7 16.2 9.4 0.73 14.3 10.7 16.6 9.4 0.18
 Digital thermography DV (°, mean±SD) 24.7 1.9 25.8 1.4 25.2 1.3 24.9 1.3 0.02* 24.4 1.6 24.4 1.5 1.0
DV max (°, mean±SD) 26.3 1.9 26.6 1.6 25.8 1.0 26.2 1.2 1.0 26.7 1.6 25.8 1.4 1.0
Lt (°, mean±SD) 28.7 2.7 26.9 2.1 31.6 2.1 31.6 2.6 <0.01* 29.7 2.9 30.8 2.5 <0.01*
Lt max (°, mean±SD) 31.9 3.1 30.4 3.3 34.9 1.0 33.8 2.8 <0.01* 34.9 0.8 34.3 0.7 <0.01*
 Synovial fluid IL-1 (pg/mL, mean±SD) 170.9 120.4 182.4 157.4 72.3 42.4 141.2 138.1 0.01* - - - - -
CRP (mg/mL, mean±SD) 0.4 1.0 0.2 0.3 0.3 1.2 0.2 0.0 0.2 - - - - -
 Weight bearing Symmetry index (mean±SD) 24.7 20.3 21.7 24.9 18.7 17.1 36.4 37.5 <0.01* 23.9 16.3 23.9 23.7 0.4
Deviation (mean±SD) 2.8 3.6 3.8 3.5 2.78 1.987 4.1 3.6 1.0 2.94 2.127 2.5 2.7 1.0
Modality 30 days 90 days 180 days
CG HG p CG HG p CG HG p
mean SD mean SD mean SD mean SD mean SD mean SD
 Goniometry Flexion (°, mean±SD) 53.6 2.9 56.3 4.5 1.0 52.7 2.9 51.7 2.6 0.03* 51.6 2.2 49.1 5.0 <0.01*
Extension (°, mean±SD) 150.8 3.4 152.0 6.0   150.8 2.9 152.0 4.7   151.3 2.9 150.7 11.5  
Thigh girth (cm, mean±SD) 30.6 2.7 29.3 2.2 0.4 31.6 2.7 31.1 5.5 1.0 31.5 2.2 31.6 4.2 1.0
Pedometer (daily steps±SD) 594.5 663.4 760.0 292.0 1.0 451.9 463.0 635.0 43.0 1.0 434.9 455.8 652.0 90.9 1.0
CMI HVAS (0–10) 6.4 1.4 6.9 1.5 0.56 6.6 1.7 6.5 1.2 0.85 6.5 1.4 6.5 1.6 0.61
CBPI—PSS (0-10) 3.7 2.6 3.0 2.6 <0.05* 4.1 2.9 2.9 2.1 0.04* 3.6 3.1 2.9 2.4 0.04*
CBPI—PIS (0-10) 3.8 2.6 3.2 2.7 0.02* 3.9 2.8 3.2 2.7 0.03* 3.5 2.4 3.2 2.7 <0.05*
COI—Stiffness (0–16) 4.6 4.1 3.5 3.8 0.11 4.6 3.9 4.0 4.0 0.49 4.0 5.7 4.3 4.3 0.81
COI—Function (0–16) 5.7 5.3 4.3 3.9 0.02* 5.0 5.2 4.1 4.1 0.02* 4.0 5.4 3.3 3.8 <0.05*
COI—Gait (0–20) 6.9 5.1 5.2 5.1 0.03* 5.7 5.5 5.0 4.9 <0.05* 4.4 5.4 6.1 5.8 0.36
COI—QOL (0–12) 5.3 3.3 4.0 2.4 0.11 5.1 2.8 4.4 2.7 0.84 4.7 2.6 4.2 2.9 0.79
COI—Overall score (0–64) 22.4 19.1 5.2 5.1 <0.01* 20.1 15.7 5.0 4.9 0.01* 15.7 14.9 19.7 17.3 0.59
LOAD (0–52) 16.4 13.1 15.0 9.7 0.09 13.1 12.4 15.3 10.8 0.56 13.1 12.4 16.4 11.8 0.99
Digital termography DV (°, mean±SD) 25.3 1.5 26.3 2.2 1.0 26.1 1.2 26.5 0.9 0.7 25.6 1.4 25.6 26.0 1.0
DV max (°, mean±SD) 25.2 2.1 27.6 2.0 <0.05* 27.4 1.4 27.5 1.2 0.2 26.9 1.4 27.4 0.9 0.3
Lt (°, mean±SD) 29.8 2.2 31.6 1.8 <0.01* 28.4 1.8 29.9 1.7 <0.01* 27.3 1.8 29.9 1.7 <0.01*
Lt max (°, mean±SD) 33.9 1.2 34.6 0.7 <0.01* 30.5 1.9 31.8 1.7 <0.01* 29.7 1.9 30.9 2.0 <0.01*
Synovial fluid IL-1 (pg/mL, mean±SD) 122.9 108.9 124.2 86.9 0.2 159.6 59.1 159.6 59.1 0.6 184.2 68.5 152.3 83.7 1.0
CRP (mg/mL, mean±SD) 0.48 0.9 0.3 0.1 0.2 0.4 0.8 0.4 0.2 0.1 0.0 0.0 0.3 0.2 1.0
Weight bearing Symmetry index (mean±SD) 18.9 12.2 14.5 15.0 <0.01* 27.4 12.1 7.6 7.5 <0.05* 27.0 27.9 5.2 3.9 0.01*
Deviation (mean±SD) 2.5 1.9 1.9 1.8 <0.01* 2.72 2.27 1.3 1.3 <0.05* 2.61 2.973 2.6 2.9 0.01*
  1. CBPI, Canine Brief Pain Inventory; CRP, C-reactive protein; COI, Canine Orthopedic Index; DV, dorsoventral view; HVAS, Hudson Visual Analogue Scale; IL-1, interleukin 1; LOAD, Liverpool Osteoarthritis in Dogs; LT, lateral view; PIS, Pain Interference Score; PSS, Pain Severity Score; QOL, quality of life
  2. *Significance when comparing the value registered by a group at an evaluation moment with T0, and comparing both group at each follow-up moment