Table 4 Functional and pathway enrichment of module 2 genes

GOTERM_BP_FAT

GO:0022617~extracellular matrix disassembly

7

5.09E−13

MMP9, ACAN, MMP3, MMP13, MMP2, MMP1, TIMP1

GOTERM_BP_FAT

GO:0030198~extracellular matrix organization

8

9.66E−12

MMP9, ACAN, SPARC, MMP3, MMP13, MMP2, MMP1, TIMP1

GOTERM_BP_FAT

GO:0043062~extracellular structure organization

8

9.86E−12

MMP9, ACAN, SPARC, MMP3, MMP13, MMP2, MMP1, TIMP1

GOTERM_CC_FAT

GO:0005578~proteinaceous extracellular matrix

8

4.33E−11

MMP9, ACAN, SPARC, MMP3, MMP13, MMP2, MMP1, TIMP1

GOTERM_CC_FAT

GO:0031012~extracellular matrix

8

6.42E−10

MMP9, ACAN, SPARC, MMP3, MMP13, MMP2, MMP1, TIMP1

GOTERM_CC_FAT

GO:0005615~extracellular space

7

2.24E−05

MMP9, IGF1, SPARC, MMP3, MMP13, MMP2, TIMP1

GOTERM_MF_FAT

GO:0004222~metalloendopeptidase activity

5

1.84E−07

MMP9, MMP3, MMP13, MMP2, MMP1

GOTERM_MF_FAT

GO:0008237~metallopeptidase activity

5

1.48E−06

MMP9, MMP3, MMP13, MMP2, MMP1

GOTERM_MF_FAT

GO:0004252~serine-type endopeptidase activity

5

4.78E−06

MMP9, MMP3, MMP13, MMP2, MMP1

KEGG_PATHWAY

hsa04066:HIF-1 signaling pathway

2

0.067876196

IGF1, TIMP1

KEGG_PATHWAY

hsa04915:Estrogen signaling pathway

2

0.069936289

MMP9, MMP2

KEGG_PATHWAY

hsa04668:TNF signaling pathway

2

0.075412069

MMP9, MMP3