Table 3 Functional and pathway enrichment of module 1 genes

GOTERM_BP_FAT

GO:1903426~regulation of reactive oxygen species biosynthetic process

6

6.31E−12

IL4, IL6, TNF, IL1B, IL10, STAT3

GOTERM_BP_FAT

GO:0032642~regulation of chemokine production

6

7.31E−12

IL4, IL6, TNF, IL1B, IL10, IL1A

GOTERM_BP_FAT

GO:0032602~chemokine production

6

1.04E−11

IL4, IL6, TNF, IL1B, IL10, IL1A

GOTERM_CC_FAT

GO:0005615~extracellular space

6

5.31E−05

IL4, IL6, TNF, IL1B, IL10, IL1A

GOTERM_CC_FAT

GO:0009897~external side of plasma membrane

3

0.004095871

IL4, IL6, TNF

GOTERM_CC_FAT

GO:0044421~extracellular region part

6

0.006314367

IL4, IL6, TNF, IL1B, IL10, IL1A

GOTERM_MF_FAT

GO:0005126~cytokine receptor binding

7

2.85E−11

IL4, IL6, TNF, IL1B, IL10, IL1A, STAT3

GOTERM_MF_FAT

GO:0005125~cytokine activity

6

3.44E−09

IL4, IL6, TNF, IL1B, IL10, IL1A

GOTERM_MF_FAT

GO:0070851~growth factor receptor binding

5

6.61E−08

IL4, IL6, IL1B, IL10, IL1A

KEGG_PATHWAY

hsa04630:Jak-STAT signaling pathway

4

1.75E−04

IL4, IL6, IL10, STAT3

KEGG_PATHWAY

hsa04668:TNF signaling pathway

3

0.00345185

IL6, TNF, IL1B

KEGG_PATHWAY

hsa04010:MAPK signaling pathway

3

0.01832436

TNF, IL1B, IL1A