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Table 2 The top six pathways in GO and KEGG enrichment analyses of the 72 genes related to both autophagy and LDD

From: Comprehensive analysis of lumbar disc degeneration and autophagy-related candidate genes, pathways, and targeting drugs

Category Term Count P value
GOTERM_BP_FAT GO:0042127~regulation of cell proliferation 46 2.12E−30
GOTERM_BP_FAT GO:0010562~positive regulation of phosphorus metabolic process 40 1.70E−29
GOTERM_BP_FAT GO:0045937~positive regulation of phosphate metabolic process 40 1.70E−29
GOTERM_BP_FAT GO:0008219~cell death 48 1.79E−28
GOTERM_BP_FAT GO:0042981~regulation of apoptotic process 43 1.85E−28
GOTERM_BP_FAT GO:0010941~regulation of cell death 44 2.20E−28
GOTERM_CC_FAT GO:0005615~extracellular space 37 5.19E−19
GOTERM_CC_FAT GO:0044421~extracellular region part 44 2.75E−10
GOTERM_CC_FAT GO:0005576~extracellular region 47 1.36E−09
GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 14 1.01E−08
GOTERM_CC_FAT GO:0009986~cell surface 18 5.52E−08
GOTERM_CC_FAT GO:0031012~extracellular matrix 15 1.25E−07
GOTERM_MF_FAT GO:0005125~cytokine activity 20 7.59E−20
GOTERM_MF_FAT GO:0005102~receptor binding 36 1.05E−18
GOTERM_MF_FAT GO:0005126~cytokine receptor binding 20 3.81E−18
GOTERM_MF_FAT GO:0008083~growth factor activity 13 5.03E−12
GOTERM_MF_FAT GO:0042802~identical protein binding 23 3.69E−08
GOTERM_MF_FAT GO:0019838~growth factor binding 9 8.56E−08
KEGG_PATHWAY hsa04060:Cytokine-cytokine receptor interaction 22 3.02E−16
KEGG_PATHWAY hsa05200:Pathways in cancer 24 4.51E−14
KEGG_PATHWAY hsa05161:Hepatitis B 16 8.20E−13
KEGG_PATHWAY hsa04210:Apoptosis 12 3.07E−12
KEGG_PATHWAY hsa04668:TNF signaling pathway 14 4.18E−12
KEGG_PATHWAY hsa04066:HIF-1 signaling pathway 13 2.18E−11
  1. GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes
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