Fig. 1

Overview of data processing step. a Transcriptomic data from 7 independent studies were selected, which included 132 OA and 74 normal samples. b Quality control and normalization for each data set. c Differential gene expression analysis of OA compared with normal was performed using “Limma” (for microarray data) or “Deseq2” (for RNA-seq data). d Strategies for integrated analysis