Fig. 7

Effects of circ_0116061 silencing and SMURF2 overexpression on the biological functions of OA chondrocytes. a OA chondrocytes were transfected with OE-NC or OE-SMURF2. WB analysis was used to measure the protein expression of SMURF2. b–n OA chondrocytes were transfected with si-NC, si-circ_0116061, si-circ_0116061 + OE-NC, or si-circ_0116061 + OE-SMURF2. Cell viability, the cell cloning number, and apoptosis rate were measured by CCK8 assay (b), colony formation assay (c), and flow cytometry (d). e–n The protein levels of Cyclin D1, Bcl2, Bax, Cleaved-casp3, IL-1β, IL-6, IL-1α, and TNFα were assessed using WB analysis. **P < 0.01, ***P < 0.001