TY - JOUR AU - Zhang, Jianping AU - Li, Na AU - Lu, Siyu AU - Chen, Yanling AU - Shan, Lequn AU - Zhao, Xingcheng AU - Xu, Yongqing PY - 2021 DA - 2021/03/29 TI - The role of Notch ligand Jagged1 in osteosarcoma proliferation, metastasis, and recurrence JO - Journal of Orthopaedic Surgery and Research SP - 226 VL - 16 IS - 1 AB - Osteosarcoma is the most common primary bone cancer occurring in young adults and the 5-year survival rate of patients with metastatic osteosarcoma is less than 30% due to high metastatic recurrence and drug resistance. Notch is a highly conserved cell to cell signaling pathway in evolution, and Jagged1 is an important ligand of Notch. Although some studies have found that Notch receptors and ligands including Jagged1 were highly expressed in osteosarcoma tissues and osteosarcoma cells, the role of Jagged1 in osteosarcoma progression and metastasis are still not clear. SN - 1749-799X UR - https://doi.org/10.1186/s13018-021-02372-y DO - 10.1186/s13018-021-02372-y ID - Zhang2021 ER -