Table 5 Pooled causes of SAEs for pTKAs

  VTE

11

[7, 15, 19, 21, 25, 28, 30, 33, 35, 36, 38]

770,255

7797

1.22

0.83–1.70

99.6

  GU complications

7 [15, 19, 25, 28, 35,36,37]

3,917,328

37,180

1.22

0.83–1.67

99.5

  Respiratory complications

10 [7, 15, 19, 21, 25, 28, 35,36,37,38]

4,358,372

44,485

0.45

0.23–0.76

99.8

  Cardiac complications

12 [7, 15, 19, 21, 25, 28, 30, 33, 35,36,37,38]

4,442,502

42,278

0.31

0.12–0.6

99.8

  Sepsis

7

[6, 15, 19, 25, 28, 30, 36]

373,454

887

0.26

0.17–0.38

97.2

  Stroke/CVA

6

[7, 19, 25, 28, 36, 37]

3,784,876

5433

0.10

0.04–0.19

97.2

  Mortality

12 [6, 7, 19, 21, 25, 28, 30, 33, 35,36,37,38]

4,370,987

11,424

0.16

0.09–0.24

99.0

  Return to OR

3

[7, 19, 28]

92,135

779

1.04

0.57–1.65

97.4

  Superficial infection

5

[15, 19, 25, 28, 36]

243,048

1066

0.43

0.21–0.72

98.6

  Deep + periprosthetic infection

12 [6, 7, 15, 19, 21, 25, 28, 30, 33, 36,37,38]

4,506,163

10,591

0.30

0.24–0.37

98.3

  Wound dehiscence

5

[19, 25, 28, 35, 37]

3,774,946

1458

0.13

0.05–0.26

98.0

  Implant-related compl.

4

[19, 28, 35, 36]

92,551

32

0.04

0.01–0.08

72.0

  Periprosthetic fractures

3

[19, 35, 36]

78,499

23

0.10

0.008–0.3

91.0