Table 3 Primary outcomes of interest based on time of patients’ enrollment
|  | Number of studies (Refs) | Sample size | Pooled estimate of effect size (%) | 95% CI | Heterogeneity (%) | χ2 test |
|---|---|---|---|---|---|---|
AE rate, before 2010 | 12 | 7,173,611 | 6.5 | 4.6−8.2 | 100 | p < 0.001 |
AE rate, from 2010 on | 6 | 639,613 | 4.7 | 1.7–9.0 | 100 | |
30-dRR, before 2010 | 6 | 3,364,870 | 5.4 | 3.8−7.3 | 100 | p < 0.001 |
30-dRR, from 2010 on | 7 | 605,587 | 4.3 | 3.2−5.6 | 100 |