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Table 3 Relationship between OPG/RANKL/RANK gene methylation rate and risk of alcohol-induced ONFH

From: OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men

Gene

Group

Number of subjects

p value

Non-methylation

Methylation

OPG1_CpG_2

Control

1

49

0.016*

Case

9

41

 

OPG3_CpG_4

Control

8

42

0.028*

Case

17

31

 

OPG4_CpG_2

Control

31

19

0.035*

Case

20

29

 

RANK1_CpG_6

Control

8

42

0.038*

Case

17

33

 

RANK3_CpG_10

Control

34

16

0.018*

Case

43

6

 

RANKL2_CpG_21

Control

25

25

0.011*

Case

36

12

 

RANKL2_CpG_46

Control

15

33

0.004**

Case

29

19

 
  1. p was calculated by the chi-squared test
  2. *p < 0.05
  3. **p < 0.01