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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes

Fig. 1

Cytotoxicity of SMN to articular chondrocytes. Human chondrocytes were incubated with the indicated concentrations of SMN for 24 h and then analysed. a SMN supplementation did not increase LDH release. b SMN additions reduced the mitochondrial activity in chondrocytes, and high-dose SMN (100 μM) further impaired cell viability. c No evidence of hypertrophic transformation or proliferation in SMN-treated chondrocytes was obtained

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