Rank | Year | First author | Article title | Key-point | Cited times |
---|---|---|---|---|---|
1 | 2003 | Sakai, D | Transplantation of mesenchymal stem cells embedded in Atelocollagen((R)) gel to the intervertebral disc: a potential therapeutic model for disc degeneration | Mesenchymal Stem Cell (Msc) | 332 |
2 | 1991 | Thompson, JP | Stimulation of mature canine intervertebral disc by growth factors | Growth Factor | 316 |
3 | 2006 | Sakai, D | Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc | MSC | 299 |
4 | 2004 | Risbud, MV | Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy | MSC | 283 |
5 | 2011 | Orozco, L | Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study | MSC | 238 |
6 | 2007 | Risbud, MV | Evidence for skeletal progenitor cells in the degenerate human intervertebral disc | Endogenous Progenitors | 208 |
7 | 2008 | Richardson, SM | Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels | Chitosan-Glycerophosphate and Msc | 202 |
8 | 2003 | Alini, M | The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix | Scaffold and Cell | 201 |
9 | 2004 | Mizuno, H | Tissue-engineered composites of anulus fibrosus and nucleus pulposus for intervertebral disc replacement | Novel Materials | 199 |
10 | 2004 | Walsh, AJL | In vivo growth factor treatment of degenerated intervertebral discs | Grow Factor | 197 |
11 | 2003 | Hunter, CJ | The notochordal cell in the nucleus pulposus: A review in the context of tissue engineering | Notochordal Cell | 196 |
12 | 2003 | Ganey, T | Disc chondrocyte transplantation in a canine model: A treatment for degenerated or damaged intervertebral disc | Autologous Chondrocyte | 194 |
13 | 2007 | Meisel, HJ | Clinical experience in cell-based therapeutics: Disc chondrocyte transplantation - A treatment for degenerated or damaged intervertebral disc | Autologous Cultured Disc-Derived Chondrocytes (ADCT) | 181 |
14 | 2006 | Sontjens, SHM | Biodendrimer-based hydrogel scaffolds for cartilage tissue repair | Hydrogel Scaffold | 169 |
15 | 2011 | Smith, LJ | Degeneration and regeneration of the intervertebral disc: lessons from development | Embryonic Morphogenesis | 167 |
16 | 2004 | Masuda, K | Growth factors and treatment of intervertebral disc degeneration | Growth Factor | 166 |
17 | 2002 | Kroeber, M | New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration | Factor and Signal | 155 |
18 | 2002 | Cs-Szabo, G | Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration | Proteoglycans | 151 |
19 | 2010 | Yoshikawa, T | Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation A Report of Two Case Studies | MSC | 149 |
20 | 2010 | Richardson, SM | Mesenchymal Stem Cells in Regenerative Medicine: Opportunities and Challenges for Articular Cartilage and Intervertebral Disc Tissue Engineering | MSC | 147 |
21 | 2006 | Chujo, T | Effects of growth differentiation factor-5 on the intervertebral disc - In vitro bovine study and in vivo rabbit disc degeneration model study | Growth Factor : rhGDF-5 | 146 |
22 | 2002 | Roughley, PJ | The role of proteoglycans in aging, degeneration and repair of the intervertebral disc | Proteoglycan | 142 |
23 | 2015 | Rosenzweig, DH | 3D-Printed ABS and PLA Scaffolds for Cartilage and Nucleus Pulposus Tissue Regeneration | Hydrogel Scaffold and MSC | 135 |
24 | 2008 | Nesti, LJ | Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam | Scaffold | 135 |
25 | 2009 | Bron, JL | Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges | MSC | 134 |
26 | 2013 | Iatridis, JC | Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair? | Biomechanics | 134 |
27 | 2009 | Ganey, T | Intervertebral Disc Repair Using Adipose Tissue-Derived Stem and Regenerative Cells Experiments in a Canine Model | Adipose Tissue-Derived Stem and Regenerative Cells (ADRC) | 133 |
28 | 2007 | Chubinskaya, S | OP-1/BMP-7 in cartilage repair | BMP-7 and Osteogenic protein-1(OP-1) | 133 |
29 | 2011 | Collin, EC | An injectable vehicle for nucleus pulposus cell-based therapy | Hydrogel and ADRC | 129 |
30 | 2008 | Masuda, K | Biological repair of the degenerated intervertebral disc by the injection of growth factors | Review: Annulus Ribrous Repair | 128 |
31 | 2016 | Richardson, SM | Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration | Growth Factor | 128 |
32 | 2005 | Zhang, YG | Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans | MSC | 127 |
33 | 2008 | Hohaus, C | Cell transplantation in lumbar spine disc degeneration disease | ADCT | 126 |
34 | 2013 | Guterl, CC | CHALLENGES AND STRATEGIES IN THE REPAIR OF RUPTURED ANNULUS FIBROSUS | Cells, Scaffold and Signal | 126 |
35 | 2007 | O'Halloran, DM | Tissue-engineering approach to regenerating the intervertebral disc | Cells, Scaffold and Signal | 119 |
36 | 2012 | Pattappa, G | Diversity of intervertebral disc cells: phenotype and function | IVD Cell Phenotype | 117 |
37 | 2002 | Takegami, K | Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1 | Interleukin-1(IL1α)+OP1 | 115 |
38 | 2008 | Ellman, MB | Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis | Cell Phenotype and MSC | 114 |
39 | 2010 | Strassburg, S | Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype | Growth Factor | 114 |
40 | 2008 | Wan, YQ | Biphasic scaffold for annulus fibrosus tissue regeneration | Scaffold | 113 |
41 | 2001 | Johnson, WEB | Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation | IVD Cell Phenotype | 111 |
42 | 2001 | Baer, AE | Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures | PNCA / KI67 | 111 |
43 | 2004 | Gorensek, M | Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes | ADCT | 105 |
44 | 2003 | An, HS | Biological repair of intervertebral disc | MSC | 104 |
45 | 2007 | Paesold, G | Biological treatment strategies for disc degeneration: potentials and shortcomings | Gene Therapy and Tissue Engineering | 103 |
46 | 2008 | Korecki, CL | Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model | Biomechanic | 102 |
47 | 2005 | Perie, D | Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability | Biomechanic | 101 |
48 | 2009 | McGirt, MJ | A Prospective Cohort Study of Close Interval Computed Tomography and Magnetic Resonance Imaging After Primary Lumbar Discectomy Factors Associated With Recurrent Disc Herniation and Disc Height Loss | Lumbar Discectomy | 100 |
49 | 2003 | Sato, M | An atelocollagen honeycomb-shaped scaffold with a membrane seal (ACHMS-scaffold) for the culture of annulus fibrosus cells from an intervertebral disc | Scaffold | 99 |
50 | 2005 | Mwale, F | Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering | Scaffold | 98 |
51 | 2010 | Shen, BJ | The Role of BMP-7 in Chondrogenic and Osteogenic Differentiation of Human Bone Marrow Multipotent Mesenchymal Stromal Cells In Vitro | BMP-7 and MSC | 97 |
52 | 2008 | Wuertz, K | Behavior of mesenchymal stem cells in the chemical microenvironment of the intervertebral disc | Inflammatory Response | 96 |
53 | 2015 | Molinos, M | Inflammation in intervertebral disc degeneration and regeneration | MSC | 96 |
54 | 2014 | Huang, YC | OPINION Intervertebral disc regeneration: do nutrients lead the way? | Disc Nutrients Supply | 96 |
55 | 2011 | Grunhagen, T | Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations of Nutrients and Metabolites | Disc Nutrients Supply | 95 |
56 | 2006 | Iatridis, JC | Effects of mechanical loading on intervertebral disc metabolism in vivo | Mechanical Loading and Disc-cell Metabolism | 94 |
57 | 2002 | Alini, M | A biological approach to treating disc degeneration: not for today, but maybe for tomorrow | Biomatrix | 93 |
58 | 2005 | Kroeber, M | Effects of controlled dynamic disc distraction on degenerated intervertebral discs - An in vivo study on the rabbit lumbar spine model | In Vivo Model | 93 |
59 | 2006 | Akeda, K | Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads | Platelet-rich Plasma(PRP) and Growth Factor | 93 |
60 | 2009 | Shen, BJ | BMP-2 Enhances TGF-beta 3-Mediated Chondrogenic Differentiation of Human Bone Marrow Multipotent Mesenchymal Stromal Cells in Alginate Bead Culture | Disc Distraction | 92 |
61 | 2007 | Chang, G | Porous silk scaffolds can be used for tissue engineering annulus fibrosus | Scaffold | 92 |
62 | 2010 | Korecki, CL | Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype | NC and MSC for NP Cell Phenotype | 91 |
63 | 2006 | Boyd, LM | Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc | Scaffold | 89 |
64 | 2007 | Revell, PA | Tissue engineered intervertebral disc repair in the pig using injectable polymers | Scaffold and MSC | 89 |
65 | 2010 | Calderon, L | TYPE II COLLAGEN-HYALURONAN HYDROGEL - A STEP TOWARDS A SCAFFOLD FOR INTERVERTEBRAL DISC TISSUE ENGINEERING | Scaffold and MSC | 89 |
66 | 2015 | Dimozi, A | OXIDATIVE STRESS INHIBITS THE PROLIFERATION, INDUCES PREMATURE SENESCENCE AND PROMOTES A CATABOLIC PHENOTYPE IN HUMAN NUCLEUS PULPOSUS INTERVERTEBRAL DISC CELLS | Oxidative stress | 88 |
67 | 2010 | Kallewaard, JW | Discogenic Low Back Pain | Low Back Pain | 87 |
68 | 2005 | Takegami, K | Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis | OP-1 | 86 |
69 | 2011 | Schek, RM | GENIPIN-CROSSLINKED FIBRIN HYDROGELS AS A POTENTIAL ADHESIVE TO AUGMENT INTERVERTEBRAL DISC ANNULUS REPAIR | Novel Materials | 85 |
70 | 2010 | Otsuki, S | Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways | Growth factor and Signal | 83 |
71 | 2005 | Magne, D | Mesenchymal stem cell therapy to rebuild cartilage | MSC | 83 |
72 | 2007 | Imai, Y | Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC | NC | 79 |
73 | 2003 | Hunter, CJ | The three-dimensional architecture of the notochordal nucleus pulposus: novel observations on cell structures in the canine intervertebral disc | OP-1 | 79 |
74 | 2013 | Ellman, MB | Fibroblast growth factor control of cartilage homeostasis | ADCT and MSC | 78 |
75 | 2011 | Purmessur, D | Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells | Growth Factor | 78 |
76 | 2011 | Acosta, FL | Porcine Intervertebral Disc Repair Using Allogeneic Juvenile Articular Chondrocytes or Mesenchymal Stem Cells | MSC | 78 |
77 | 2006 | Masuda, K | Prevention of disc degeneration with growth factors | Growth Factor | 75 |
78 | 2013 | Frith, JE | An injectable hydrogel incorporating mesenchymal precursor cells and pentosan polysulphate for intervertebral disc regeneration | Directly Repair | 72 |
79 | 2000 | Ahlgren, BD | Effect of anular repair on the healing strength of the intervertebral disc - A sheep model | Hydrogel Scaffold and MPC (mesenchymal precursor cell) | 72 |
80 | 2006 | Wilda, H | In vitro studies of annulus fibrosus disc cell attachment, differentiation and matrix production on PDLLA/45S5 Bioglass (R) composite films | Aggrecan | 69 |
81 | 2014 | Sivan, SS | Structure, function, aging and turnover of aggrecan in the intervertebral disc | Composite Film | 69 |
82 | 2012 | Whatley, BR | Intervertebral disc (IVD): Structure, degeneration, repair and regeneration | IVD Regeneration | 65 |
83 | 2006 | Iwashina, T | Low-intensity pulsed ultrasound stimulates cell proliferation and proteoglycan production in rabbit intervertebral disc cells cultured in alginate | Proteoglycan | 63 |
84 | 2015 | Tsaryk, R | Collagen-low molecular weight hyaluronic acid semi-interpenetrating network loaded with gelatin microspheres for cell and growth factor delivery for nucleus pulposus regeneration | Hydrogel | 62 |
85 | 2006 | Masuoka, K | Tissue engineering of articular cartilage with autologous cultured adipose tissue-derived stromal cells using atelocollagen honeycomb-shaped scaffold with a membrane sealing in rabbits | Scaffold and ATSC | 61 |
86 | 2010 | Chang, G | Enhancing annulus fibrosus tissue formation in porous silk scaffolds | Scaffold | 60 |
87 | 2013 | Hudson, KD | Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intenrertebral discs | Scaffold | 60 |
88 | 2004 | Masuda, K | Growth factors and the intervertebral disc | Growth Factor | 58 |
89 | 2013 | Francisco, AT | Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration | Hydrogel | 58 |
90 | 2012 | Chan, SCW | Intervertebral disc regeneration or repair with biomaterials and stem cell therapy - feasible or fiction? | Hydrogel and MSC | 58 |
91 | 2008 | Abbushi, A | Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration | PGA(polyglycolic acid) Implant | 58 |
92 | 2001 | Pattison, ST | Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by transforming growth factor-beta(1) and insulin like growth factor-I | Growth Factor: MMP and TGF-β1 | 57 |
93 | 2011 | Mwale, F | The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration | Synthetic Peptides(link N) | 56 |
94 | 2009 | Mavrogonatou, E | High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response | DNA repair | 55 |
95 | 2012 | Milani, AH | Injectable Doubly Cross-Linked Microgels for Improving the Mechanical Properties of Degenerated Intervertebral Discs | Scaffold | 54 |
96 | 2013 | Salgado, AJ | Tissue Engineering and Regenerative Medicine: Past, Present, and Future | Scaffold and ADCT | 54 |
97 | 2005 | Masuoka, K | Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold) | TERM | 54 |
98 | 2012 | Vadala, G | Bioactive electrospun scaffold for annulus fibrosus repair and regeneration | Gene and Protein Expression | 53 |
99 | 2017 | Dowdell, J | Intervertebral Disk Degeneration and Repair | PRP and Growth Factor | 53 |
100 | 2013 | Brisby, H | The Presence of Local Mesenchymal Progenitor Cells in Human Degenerated Intervertebral Discs and Possibilities to Influence These In Vitro: A Descriptive Study in Humans | Scaffold and MSC | 53 |