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Table 1 Urine fluorine, serum BALP content and bone tissue Ihh, Shh, Ptch1, and Smo mRNA expression in each group

From: The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury

Groups The number of cases The urinary fluoride content(mg/L) BALP(IU/L) Ihh Smo Gli2 Runx2
Control group 12 1.36 ± 0.51 27.78 ± 4.09 0.73 ± 0.19 0.14 ± 0.04 0.83 ± 0.19 0.37 ± 0.10
F group 12 7.60 ± 0.61* 57.46 ± 3.99* 1.39 ± 0.36* 0.40 ± 0.15* 1.40 ± 0.31* 0.57 ± 0.19*
F + Cycl group 12 7.55 ± 0.32* 53.55 ± 2.22*#& 0.81 ± 0.28#& 0.16 ± 0.03#& 0.75 ± 0.17#& 0.42 ± 0.09#&
F + DMSO group 12 7.55 ± 0.19* 57.56 ± 4.23* 1.31 ± 0.34* 0.39 ± 0.10* 1.26 ± 0.35* 0.55 ± 0.17*
  1. *Compared with control group, P < 0.05
  2. #Compared with F group, P < 0.05
  3. &Compared with F + DMSO group, P < 0.05