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Table 1 Urine fluorine, serum BALP content and bone tissue Ihh, Shh, Ptch1, and Smo mRNA expression in each group

From: The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury

Groups

The number of cases

The urinary fluoride content(mg/L)

BALP(IU/L)

Ihh

Smo

Gli2

Runx2

Control group

12

1.36 ± 0.51

27.78 ± 4.09

0.73 ± 0.19

0.14 ± 0.04

0.83 ± 0.19

0.37 ± 0.10

F group

12

7.60 ± 0.61*

57.46 ± 3.99*

1.39 ± 0.36*

0.40 ± 0.15*

1.40 ± 0.31*

0.57 ± 0.19*

F + Cycl group

12

7.55 ± 0.32*

53.55 ± 2.22*#&

0.81 ± 0.28#&

0.16 ± 0.03#&

0.75 ± 0.17#&

0.42 ± 0.09#&

F + DMSO group

12

7.55 ± 0.19*

57.56 ± 4.23*

1.31 ± 0.34*

0.39 ± 0.10*

1.26 ± 0.35*

0.55 ± 0.17*

  1. *Compared with control group, P < 0.05
  2. #Compared with F group, P < 0.05
  3. &Compared with F + DMSO group, P < 0.05