Table 3 Evaluation of the association between GDF5 gene polymorphisms and KOA susceptibility

Allele model (C versus T)

Overall

0.83 [0.74, 0.93]

<0.00001

77%

0.79 [0.73, 0.87]

0.009

54%

Caucasian

0.82 [0.72, 0.93]

0.23

30%

0.82 [0.72, 0.93]

0.23

30%

Asian

0.83 [0.70, 0.99]

<0.00001

86%

0.78 [0.68, 0.88]

0.002

69%

African

0.89 [0.59, 1.34]

0.39

0%

0.89 [0.59, 1.34]

0.39

0%

Dominant model (CC + CT versus TT)

Overall

0.78 [0.67, 0.90]

<0.00001

74%

Caucasian

0.74 [0.58, 0.94]

0.06

59%

Asian

0.79 [0.65, 0.96]

<0.00001

81%

African

0.86 [0.26, 2.78]

0.06

72%

Recessive model (CC versus CT + TT)

Overall

0.80 [0.65, 0.99]

0.0002

65%

0.76 [0.68, 0.86]

0.73

0%

Caucasian

0.83 [0.69, 1.00]

0.80

0%

0.83 [0.69, 1.00]

0.80

0%

Asian

0. 78 [0.55, 1.10]

<0.00001

79%

0.71 [0.60, 0.83]

0.52

0%

African

0.91 [0.47, 1.76]

0.51

0%

0.91 [0.47, 1.76]

0.51

0%

Heterozygous model (CT versus TT)

Overall

0.79 [0.69, 0.91]

<0.0001

68%

Caucasian

0.75 [0.58, 0.98]

0.05

62%

Asian

0.80 [0.68, 0.96]

0.0003

73%

African

0.88 [0.17, 4.46]

0.02

82%

Homozygous model (CC versus TT)

Overall

0.70 [0.55, 0.90]

<0.00001

72%

0.66 [0.58, 0.76]

0.39

6%

Caucasian

0.73 [0.60, 0.89]

0.54

0%

0.73 [0.60, 0.89]

0.54

0%

Asian

0.69 [0.47, 1.03]

<0.00001

83%

0.61 [0.50, 0.74]

0.22

26%

African

0.81 [0.38, 1.72]

0.54

0%

0.81 [0.38, 1.72]

0.54

0%