Table 1 Characteristics of published studies for associations between GDF5 gene polymorphisms and KOA. Genotype and allelic distribution of GDF5 (C/T) gene polymorphisms among KOA patients and control individuals
Author, Year | Country | Population | Genotyping method | Case (KOA)/control (healthy) | Allele | Case | Allele | Control | HWE | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C | T | CC (%) | CT (%) | TT (%) | C | T | CC (%) | CT (%) | TT (%) | ||||||
Miyamoto, 2007 [14] | Japan | Asian | TaqMan | 718/861 | 305 | 1131 | 31 (4.32) | 243 (33.84) | 444 (61.84) | 446 | 1276 | 58 (6.74) | 330 (38.32) | 473 (54.94) | 0.965618 |
| Â | China | Asian | 313/485 | 135 | 491 | 19 (6.07) | 97 (30.99) | 197 (62.94) | 289 | 681 | 48 (9.90) | 193 (39.79) | 244 (50.31) | 0.28277 | |
Tsezou, 2008 [20] | Greece | Caucasian | DNA sequencer | 251/267 | 186 | 316 | 30 (11.95) | 126 (50.20) | 95 (37.85) | 213 | 323 | 44 (16.42) | 125 (46.64) | 99 (36.94) | 0.668599 |
Yao, 2008 [23] | China | Asian | RT-qPCR | 313/485 | 135 | 491 | 19 (6.07) | 97 (30.99) | 197 (62.94) | 289 | 681 | 48 (9.90) | 193 (39.79) | 244 (50.31) | 0.28277 |
Vaes, 2009Â [21] | Netherland | Caucasian | TaqMan | 667/2764 | 484 | 850 | 93 (13.94) | 298 (44.68) | 276 (41.38) | 2160 | 3368 | 424 (15.34) | 1312 (47.47) | 1028 (37.19) | 0.872858 |
Valdes, 2009Â [22] | UK | Caucasian | AS-PCR | 259/509 | 168 | 350 | 35 (13.51) | 98 (37.84) | 126 (48.65) | 412 | 606 | 84 (16.50) | 244 (47.94) | 181 (35.56) | 0.907919 |
Takahashi, 2010 [18] | Japan | Asian | TaqMan | 933/1225 | 421 | 1445 | 54 (5.79) | 313 (33.55) | 566 (60.66) | 621 | 1829 | 80 (6.53) | 461 (37.63) | 684 (55.84) | 0.844647 |
Cao, 2010Â [11] | Korea | Asian | PCR-RFLP | 276/298 | 137 | 415 | 11 (3.99) | 115 (41.68) | 150 (54.35) | 165 | 431 | 26 (8.72) | 113 (37.92) | 159 (53.36) | 0.3605 |
Tawonsawatruk, 2011 [19] | Thailand | Asian | PCR-RFLP | 90/103 | 63 | 117 | 11 (12.22) | 41 (45.56) | 38 (42.22) | 93 | 113 | 23 (22.33) | 47 (45.63) | 33 (32.04) | 0.424487 |
Shin, 2012 [17] | Korea | Asian | HRMA | 725/1737 | 381 | 1069 | 38 (5.24) | 305 (42.07) | 382 (52.69) | 901 | 2573 | 106 (6.10) | 689 (39.67) | 942 (54.23) | 0.17575 |
Mishra, 2017 [13] | India | Asian | PCR-RFLP | 500/500 | 376 | 624 | 75 (15.00) | 226 (45.20) | 199 (39.80) | 466 | 534 | 97 (19.40) | 272 (54.40) | 131 (26.20) | 0. 37456 |
Ozcan, 2017 [16] | Turkey | Caucasian | PCR-RFLP | 94/279 | 71 | 117 | 14 (14.89) | 43 (45.74) | 37 (39.36) | 257 | 301 | 52 (18.64) | 153 (54.84) | 74 (26.52) | 0.083439 |
Elazeem, 2017 [12] | Egypt | African | TaqMan | 50/50 | 44 | 56 | 14 (28.00) | 16 (32.00) | 20 (40.00) | 51 | 49 | 13 (26.00) | 25 (50.00) | 12 (24.00) | 0.997742 |
Zhang, 2019 [24] | China | Asian | PCR-RFLP | 288/397 | 223 | 353 | 59 (20.49) | 105 (36.45) | 124 (43.06) | 223 | 571 | 32 (8.06) | 159 (40.05) | 206 (52.39) | 0.864938 |
Mohasseb, 2019 [15] | Egypt | African | PCR-RFLP | 47/40 | 43 | 51 | 10 (21.28) | 23 (48.94) | 14 (29.78) | 35 | 45 | 11 (27.50) | 13 (32.50) | 16 (40.00) | 0. 31687 |