Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials

Shi, Lijun; Zhu, Haiyun; Ma, Jinhui; Shi, Li-Li; Gao, Fuqiang; Sun, Wei

doi:10.1186/s13018-021-02264-1

Journal of Orthopaedic Surgery and Research

Table 1 Main characteristics of the 11 included studies

From: Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials

Author, year	Country	Groups (n)	Interventions	Age (y), %Males	Type of arthroscopy	Anesthesia	Main outcomes
Sadoni, 2017 [28]	Iran	Mg: 51	Mg 1 g + saline to 20 ml	30.6 ± 7.6, 82.3%	Meniscectomy	General	VAS, AC, AD
Sadoni, 2017 [28]	Iran	P: 43	Saline 20 ml	29.9 ± 9.5, 79.0%	Meniscectomy	General	VAS, AC, AD
Devi, 2018 [29]	India	Mg + B: 18	Mg 10 mg/kg + 0.25% B to 20 ml	33.44 ± 10.87, 72.2%	Arthroscopy	Spinal	VAS, AC
Devi, 2018 [29]	India	B: 18	0.25% B 20 ml	37.22 ± 13.36, 55.5%	Arthroscopy	Spinal	VAS, AC
Abdulatif, 2015 [30]	Egypt	Mg: 28	Mg 1 g + saline to 20 ml	34.6 ± 9.3, 60.7%	ACL reconstruction	FNB + General	VAS, AC, AD, SE
Abdulatif, 2015 [30]	Egypt	P: 27	Saline 20 ml	35.0 ± 10.4, 74.0%	ACL reconstruction	FNB + General	VAS, AC, AD, SE
FAROUK, 2009 [31]	Egypt	Mg + B: 20	Mg 0.15 g + 0.25% B to 20 ml	36 ± 6, 90%	Meniscectomy	General	VAS, AC, AD
FAROUK, 2009 [31]	Egypt	B: 20	0.25% B 20 ml	35 ± 7, 80%	Meniscectomy	General	VAS, AC, AD
Radwan, 2012 [32]	Egypt	Mg: 20	Mg 0.8 g + saline to 20 ml	31.10 ± 7.90, 85%	Meniscectomy	General	VAS, AC, AD, SE
Radwan, 2012 [32]	Egypt	B: 20	0.5% B 20 ml	32.20 ± 9.62, 90%	Meniscectomy	General	VAS, AC, AD, SE
Koltka, 2011 [33]	Turkey	Mg: 30	Mg 0.5 g + saline to 20 ml	48.4 ± 11, 30%	Meniscectomy	General	NRS, AC, AD
Koltka, 2011 [33]	Turkey	P: 30	Saline 20 ml	46.0 ± 15.6, 36.6%	Meniscectomy	General	NRS, AC, AD
Suhrita, 2009 [34]	Kolkata	Mg + B: 30	Mg 0.5 g+ 0.25% B to 20 ml	37.9 ± 11.8, 36.6%	Meniscectomy, Ligament repair	General	VAS, AC, AD, SE
Suhrita, 2009 [34]	Kolkata	B: 30	0.25% B + saline to 20 ml	36.8 ± 10.6, 70%	Meniscectomy, Ligament repair	General	VAS, AC, AD, SE
Kizilcik, 2017 [35]	Turkey	Mg + LB: 32	Mg 1.5 g + LB 50 mg to 15 ml	43.06 ± 13.19, 68.7%	Meniscectomy	General	VAS, AC, SE
Kizilcik, 2017 [35]	Turkey	LB: 32	LB 100 mg 10 ml	40.06 ± 9.24, 75%	Meniscectomy	General	VAS, AC, SE
Bondok, 2006 [36]	Egypt	Mg: 30	Mg 0.5 g + saline to 10 ml	27 ± 4, 100%	Meniscectomy	General	VAS, AC, AD
Bondok, 2006 [36]	Egypt	P: 30	Saline 10 ml	25 ± 4, 100%	Meniscectomy	General	VAS, AC, AD
Elsharnouby, 2008 [37]	Egypt	Mg: 27 P: 27	Mg 1 g + saline to 20 ml Saline 20 ml	39 ± 12, 11.1% 41 ± 13, 14.8%	Meniscectomy	General	VAS, AC, AD
Elsharnouby, 2008 [37]	Egypt	Mg + B: 27 B: 27	Mg 1 g + 0.25% B to 20 ml 0.25% B 20 ml	40 ± 11, 3.7% 45 ± 9, 7.4%	Meniscectomy	General	VAS, AC, AD
Venkateshamurthy, 2018 [38]	India	Mg + B: 30	Mg 1 g + 0.25% B to 30 ml	Un	Arthroscopy	General	VAS, AC, AD
Venkateshamurthy, 2018 [38]	India	B: 30	0.5% B + saline to 30 ml	Un	Arthroscopy	General	VAS, AC, AD

Mg magnesium sulfate, B bupivacaine, P placebo, LB levobupivacaine, ACL anterior cruciate ligament, Un unknown, FNB femoral nerve block, VAS visual analog scale score, NRS numeric rating scale, AC analgesic consumption, AD analgesic consumption duration, SE side effects

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ISSN: 1749-799X

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