Fig. 2

Co-treatment with disulfiram and glycyrrhizic acid promoted the proliferation and alleviated the inflammation in chondrocytes. (a-b) After co-treatment with disulfiram and glycyrrhizic acid, the cell proliferation of chondrocytes induced by LPS and ATP was detected by CCK-8 assay. (c) After co-treatment with disulfiram and glycyrrhizic acid, the levels of pyroptosis-related inflammatory factors were detected by ELISA. (d-e) After co-treatment with disulfiram and glycyrrhizic acid, the protein and mRNA levels of pyroptosis-related proteins were detected by western blot and PCR, respectively. *P < 0.05, **P < 0.01, and ***P < 0.001