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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Fig. 7

hMSC-derived exosomal HAND2-AS1 suppresses tumor-like biologic behaviors of RA-FLSs via NF-κB pathway. a–h MH7A cells were incubated with HAND2-AS1-Exos or vector-Exos. a qRT-PCR analysis of miR-143-3p expression in MH7A cells. b Western blot analysis of TNFAIP3 expression in MH7A cells. c Cell proliferation analysis with CCK-8. d Flow cytometric analysis of cell apoptosis. e Cell migration analysis using wound healing assay. f Transwell assay of cell invasion. g Detection of IL-6 and TNF-α levels in cells with ELISA. h Western blot analysis of the level of p-p65 and p65. *P < 0.05, **P < 0.001, ***P < 0.0001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X