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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Mesenchymal stem cell-originated exosomal lncRNA HAND2-AS1 impairs rheumatoid arthritis fibroblast-like synoviocyte activation through miR-143-3p/TNFAIP3/NF-κB pathway

Fig. 5

Knockdown of TNFAIP3 reverses the effects of HAND2-AS1 overexpression on RA-FLSs. a Western blot analysis of TNFAIP3 expression in MH7A cells transfected with si-NC or si-TNFAIP3. bg MH7A cells were transfected with vector + si-NC, HAND2-AS1 + si-NC, or HAND2-AS1 + si-TNFAIP3. b CCK-8 assay of cell proliferation. c Flow cytometric analysis of cell apoptosis. d Wound healing assay of cell migration. e Transwell assay of cell invasion. f Detection of IL-6 and TNF-α levels in cells with ELISA. g Western blot analysis of the level of p-p65 and p65. **P < 0.001, ***P < 0.0001

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