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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: MiR-140-3p inhibits the cell viability and promotes apoptosis of synovial fibroblasts in rheumatoid arthritis through targeting sirtuin 3

Fig. 1

MiR-140-3p was low-expressed in RASFs and targeted SIRT3 and SIRT1. a The expression of miR-140-3p in RASFs and NSFs was detected by RT-qPCR; U6 was used as an internal control. (^^P < 0.01, vs. NSFs). b, e SIRT3-3′-UTR and SIRT1-3′-UTR containing binding sites of miR-140-3p was predicted by TargetScan. b, c, f, g Luciferase assay validated that miR-140-3p targeted SIRT3 and SIRT1 in 293T cells (*P < 0.05, **P < 0.01, ***P < 0.001, vs. control). All experiments were conducted three times. (RASFs, rheumatoid arthritis synovial fibrous tissues; NSFs, normal synovial fibrous tissues; SIRT3, sirtuin 3)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X