Table 3 Details of the side effects

Day 1 nausea

0.07

0.59

0.16

 Yes

26 (32%)

25 (20%)

2 (17%)

4 (11%)

24 (34%)

21 (25%)

 No

56 (68%)

99 (80%)

10 (73%)

33 (89%)

46 (66%)

66 (75%)

Day 1 vomit

0.08

0.43

0.31

 Yes

14 (18%)

13 (10%)

1 (8%)

1 (3%)

13 (20%)

12 (14%)

 No

64 (82%)

111 (90%)

12 (92%)

36 (97%)

52 (80%)

75 (86%)

Day 1 pruritus

0.90

0.54

0.69

 Yes

2 (3%)

3 (3%)

0 (0%)

1 (3%)

2 (4%)

2 (2%)

 No

68 (97%)

117 (97%)

13 (100%)

35 (97%)

55 (96%)

82 (98%)

Day 1 sedation

0.20

0.86

0.22

 Yes

10 (13%)

9 (7%)

1 (7%)

2 (5%)

9 (14%)

7 (8%)

 No

68 (87%)

115 (93%)

14 (93%)

35 (95%)

54 (86%)

80 (92%)

Day 2 nausea

0.02

0.12

0.09

 Yes

21 (26%)

16 (13%)

3 (25%)

3 (8%)

18 (26%)

13 (15%)

 No

61 (74%)

108 (87%)

9 (75%)

34 (92%)

52 (74%)

74 (75%)

Day 2 vomit

0.05

0.13

0.91

 Yes

6 (8%)

12 (10%)

2 (13%)

2 (5%)

4 (6%)

10 (11%)

 No

71 (92%)

112 (90%)

13 (87%)

35 (95%)

58 (74%)

77 (89%)

Day 2 pruritus

0.77

–

0.85

 Yes

1 (1%)

1 (0%)

0 (0%)

0 (0%)

1 (2%)

1 (1%)

 No

69 (99%)

105 (100%)

13 (100%)

35 (100%)

56 (98%)

73 (99%)

Day 2 sedation

0.20

0.85

0.10

 Yes

5 (6%)

3 (3%)

1 (7%)

2 (6%)

4 (6%)

1 (1%)

 No

72 (94%)

111 (97%)

13 (93%)

33 (94%)

58 (94%)

78 (99%)