Fig. 6

H&E stained section of the femoral explant showing new bone formation at 7 weeks. Panel a shows implanted V-CBA fibers with new bone formation between the fibers as well as neovascularization (top rectangle, expanded for better viewing). The bottom rectangle shows V-CBA bone chips (*) with new bone formation (#). Panel b shows the magnified area within the lower rectangle in panel a. Within the newly formed bone, osteocytes (yellow arrows) occupy the spaces within the lacunae. Osteoblasts (black arrow), with their characteristic cuboidal shape, can be seen along the edges of the newly formed bone depositing bone matrix. Osteoclasts (red arrow) with large multinucleated morphology are leading the new bone formation path for osteoblasts. Merged multiple 10× images (a) and 10× image (b)