Fig. 2

GO and KEGG analysis of DEGs and PPI network construction. The GO and KEGG analysis were performed based on the identified DEGs using clusterProfiler package of R. The top 10 significant biological process (a) and cellular component (b) GO terms, and the 11 remarkable molecular function GO terms (c) were demonstrated. The right half-circle was the enriched GO terms, which were presented in different colors. The left half-circle was the gene enriched in these terms, in which red represented upregulation and blue represented downregulation. d The top 15 notable KEGG pathways were shown in the bar plot. The y-axis was the name of signaling pathways and the x-axis was the gene number. e PPI network based on the identified DEGs was constructed in the STRING online database. Each dot represented a node and the number of lines connected to the dot represented the degree of the node. The red represented the upregulated genes and the green represented the downregulated genes. The blue triangle was the Cluster1 and the blue diamond was the Cluster2