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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model

Fig. 5

Gene expression of LPS-stimulated chondrocytes when co-cultured with MSCs, PDGF-MSCs, or HO-1-MSCs. a, b Pro-inflammatory factors after 24 and 72 h of incubation. c, d Chondrogenic marker expression. e, f Expression of hypertrophic (MMP-13), fibrotic (COL1α1), and pain-related (NGF) markers. Data are shown as fold change compared to chondrocytes alone. *P < 0.05 and **P < 0.01 compared to the control. #P < 0.05 and ##P < 0.01 compared to the LPS group. P < 0.05 and ††P < 0.01, a significant difference between the indicated groups

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