The efficacy and safety of high-dose tranexamic acid in adolescent idiopathic scoliosis: a meta-analysis

Table 2 Characteristics of the included studies

Study	Age		No. of patients		Study design	Participants	Intervention	Comparison	Level of fused		Transfusion criteria	Surgery	Body weight (kg)
Study	TXA	C	TXA	C			TXA	C	TXA	C			TXA	C
Ng et al. [10]	15.16	15.3	55	35	RCS	Patients received ASS	100 mg/kg + 10 mg/kg/h	No TXA	13.5	12.1	Hb < 8 g/dL	PSF	45.25	42.88
da Rocha et al. [11]	18	21.6	21	19	RCS	Patients received ASS	100 mg/kg + 30 mg/kg/h	No TXA	9.4	9.2	Not reported	PSF	55.5	51.8
Sethna et al. [12]	13.6	14	23	21	RCT	Patients received ASS	100 mg/kg + 10 mg/kg/h	NS 0.9%	14	13	Hb < 9 g/dL	PSF	59.4	52.4
Lykissas et al. [13]	14.7	13.5	25	24	RCS	Patients received ASS	100 mg/kg + 10 mg/kg/h	No TXA	10.7	12.6	Hb < 7 g/dL	PSF	Not reported
Goobie et al. [14]	14.9	14.7	56	55	RCT	Patients received ASS	50 mg/kg + 10 mg/kg/h	NS 0.9%	10	9	Hb ≤7.3 g/dL	PSF	55.1	51.6

TXA tranexamic acid, C control, PSF posterior spinal fusion, NS normal saline, RCS retrospective cohort studies, RCT randomized control trials, ASS adolescent scoliosis surgery

ISSN: 1749-799X