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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Homoharringtonine inhibits fibroblasts proliferation, extracellular matrix production and reduces surgery-induced knee arthrofibrosis via PI3K/AKT/mTOR pathway-mediated apoptosis

Fig. 6

HHT induced fibroblasts apoptosis via inhibiting the activation of PI3K/AKT/mTOR signaling pathway. a We treated fibroblasts with different doses of HHT for 24 h. The results of western blot assay showed that the expression of phosphorylation levels of PI3K, AKT, and mTOR were significantly reduced after the application of HHT in a dose-dependent manner. b After the treatment of IGF-1, an activator of PI3K/AKT axis, the expressions of pro-apoptosis-related proteins were decreased, c and the fibroblast apoptosis rate was also suppressed

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X