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Table 4 List of significantly downregulated DEGs involved in osteoarthritis susceptibility

From: Investigating the molecular control of deer antler extract on articular cartilage

Gene name Expression level (FPKM) log2 fold change (DAE/Blank) p value
Blank DAE
Collagen alpha-1(I) chain (Col1a1) 6244.47 2741.45 − 1.19 0
Protein S100-A4 (S100a4) 687.97 330.60 − 1.06 2.85E−77
Fatty acid-binding protein (Fabp4) 150.74 74.48 − 1.02 1.22E−22
Collagen alpha-1(IV) chain (Col4a1) 60.42 26.01 − 1.22 1.55E−166
Cyclic AMP-responsive element-binding protein 3-like protein 1 (Creb3l1) 53.52 23.54 − 1.18 1.14E−56
C-C motif chemokine 9 (Ccl9) 34.51 11.42 − 1.60 2.15E−27
Retinoid-binding protein 7 (Rbp7) 19.22 5.96 − 1.69 1.21E−07
Neurogenic locus notch homolog protein 3 (Notch3) 18.11 8.55 − 1.08 1.69E−47
C-X-C motif chemokine 16 (Cxcl16) 17.30 7.62 − 1.18 1.19E−12
Receptor activity-modifying protein 3 (Ramp3) 16.14 6.77 − 1.25 2.83E−09
Cytochrome P450 1B1 (Cyp1b1) 15.63 6.84 − 1.19 1.50E−15
Proprotein convertase subtilisin/kexin type 1 inhibitor (Pcsk1n) 15.53 6.80 − 1.19 1.73E−06
Homeobox protein DLX-3 (Dlx3) 15.49 7.31 − 1.08 3.27E−15
Protein naked cuticle homolog 2 (Nkd2) 14.53 6.59 − 1.14 1.00E−22
Matrix metalloproteinase-19 (Mmp19) 12.71 6.07 − 1.07 2.53E−09
Endosialin (Cd248) 11.69 5.06 − 1.21 2.00E−13
Pentraxin-related protein PTX3 (Ptx3) 10.83 5.32 − 1.03 1.16E−07
Fc receptor-like protein 2 (Fcrl2) 10.76 4.82 − 1.16 1.76E−10
Serine protease HTR4 (Htra4) 10.74 4.32 − 1.31 2.14E−12
Transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1) 10.61 5.05 − 1.07 3.56E−08
Apelin receptor (Aplnr) 10.59 3.76 − 1.49 2.16E−23
Tubulin beta-2B chain (Tubb2b) 7.26 3.04 − 1.26 1.80E−06
Arginase-1 (Arg1) 5.65 2.37 − 1.25 8.66E−05
Nostrin (Nostrin) 5.43 2.16 − 1.33 1.80E−05
von Willebrand factor (Vwf) 3.76 1.63 − 1.21 3.03E−15
Tenascin-X (Tnxb) 2.82 1.27 − 1.15 4.95E−05
Aryl hydrocarbon receptor (Ahr) 2.41 1.16 − 1.05 1.62E−05
Interferon-induced protein with tetratricopeptide repeats 1 (Ifit1) 2.01 0.54 − 1.90 1.02E−04
Interleukin-2 receptor subunit beta (Il2rb) 1.91 0.59 − 1.69 1.31E−04
Chloride intracellular channel protein 5 (Clic5) 1.81 0.51 − 1.83 1.62E−09
C-type lectin domain family 9 member A (Clec9a) 1.47 0.43 − 1.77 9.17E−05