Table 4 List of significantly downregulated DEGs involved in osteoarthritis susceptibility

Collagen alpha-1(I) chain (Col1a1)

6244.47

2741.45

− 1.19

0

Protein S100-A4 (S100a4)

687.97

330.60

− 1.06

2.85E−77

Fatty acid-binding protein (Fabp4)

150.74

74.48

− 1.02

1.22E−22

Collagen alpha-1(IV) chain (Col4a1)

60.42

26.01

− 1.22

1.55E−166

Cyclic AMP-responsive element-binding protein 3-like protein 1 (Creb3l1)

53.52

23.54

− 1.18

1.14E−56

C-C motif chemokine 9 (Ccl9)

34.51

11.42

− 1.60

2.15E−27

Retinoid-binding protein 7 (Rbp7)

19.22

5.96

− 1.69

1.21E−07

Neurogenic locus notch homolog protein 3 (Notch3)

18.11

8.55

− 1.08

1.69E−47

C-X-C motif chemokine 16 (Cxcl16)

17.30

7.62

− 1.18

1.19E−12

Receptor activity-modifying protein 3 (Ramp3)

16.14

6.77

− 1.25

2.83E−09

Cytochrome P450 1B1 (Cyp1b1)

15.63

6.84

− 1.19

1.50E−15

Proprotein convertase subtilisin/kexin type 1 inhibitor (Pcsk1n)

15.53

6.80

− 1.19

1.73E−06

Homeobox protein DLX-3 (Dlx3)

15.49

7.31

− 1.08

3.27E−15

Protein naked cuticle homolog 2 (Nkd2)

14.53

6.59

− 1.14

1.00E−22

Matrix metalloproteinase-19 (Mmp19)

12.71

6.07

− 1.07

2.53E−09

Endosialin (Cd248)

11.69

5.06

− 1.21

2.00E−13

Pentraxin-related protein PTX3 (Ptx3)

10.83

5.32

− 1.03

1.16E−07

Fc receptor-like protein 2 (Fcrl2)

10.76

4.82

− 1.16

1.76E−10

Serine protease HTR4 (Htra4)

10.74

4.32

− 1.31

2.14E−12

Transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1)

10.61

5.05

− 1.07

3.56E−08

Apelin receptor (Aplnr)

10.59

3.76

− 1.49

2.16E−23

Tubulin beta-2B chain (Tubb2b)

7.26

3.04

− 1.26

1.80E−06

Arginase-1 (Arg1)

5.65

2.37

− 1.25

8.66E−05

Nostrin (Nostrin)

5.43

2.16

− 1.33

1.80E−05

von Willebrand factor (Vwf)

3.76

1.63

− 1.21

3.03E−15

Tenascin-X (Tnxb)

2.82

1.27

− 1.15

4.95E−05

Aryl hydrocarbon receptor (Ahr)

2.41

1.16

− 1.05

1.62E−05

Interferon-induced protein with tetratricopeptide repeats 1 (Ifit1)

2.01

0.54

− 1.90

1.02E−04

Interleukin-2 receptor subunit beta (Il2rb)

1.91

0.59

− 1.69

1.31E−04

Chloride intracellular channel protein 5 (Clic5)

1.81

0.51

− 1.83

1.62E−09

C-type lectin domain family 9 member A (Clec9a)

1.47

0.43

− 1.77

9.17E−05