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Table 3 List of significantly upregulated DEGs involved in cartilage formation, growth, and repair

From: Investigating the molecular control of deer antler extract on articular cartilage

Gene name Expression level (FPKM) log2 fold change (DAE/Blank) p value
Blank DAE
Hyaluronan and proteoglycan link protein 1 (Hapln1) 301.97 901.64 1.58 0
Collagen alpha-1(IX) chain (Col9a1) 142.16 519.76 1.87 0
Scrapie-responsive protein 1 (Scrg1) 203.52 491.32 1.27 1.23E−92
Cartilage oligomeric matrix protein (Comp) 230.34 490.17 1.09 0
Leukocyte cell-derived chemotaxin 1 (Cnmd) 135.34 397.34 1.55 1.08e−321
Carbonic anhydrase 2 (Ca2) 172.19 352.43 1.03 2.61E−159
Matrilin-3 (Matn3) 112.11 292.66 1.38 0
Transferrin receptor protein 1 (Tfrc) 46.77 117.84 1.33 1.65E−274
Vascular endothelial growth factor A (Vegfa) 51.06 107.19 1.07 8.57E−143
Collagen alpha-1(XXVII) chain (Col27a1) 41.63 90.66 1.12 2.44E−248
M-phase inducer phosphatase 2 (Cdc25b) 33.93 76.00 1.16 1.82E−92
Proliferation marker protein Ki-67 (Mki67) 21.76 45.38 1.06 6.36E−136
Carbonic anhydrase 12 (Ca12) 10.53 35.95 1.77 2.03E−95
Radical S-adenosyl methionine domain-containing protein 2 (Rsad2) 9.91 29.91 1.59 1.27E−69
T cell acute lymphocytic leukemia protein 1 homolog (Tal1) 10.64 23.50 1.14 2.07E−44
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (Csgalnact1) 11.15 22.80 1.03 3.03E−18
Cartilage matrix protein (Matn1) 4.78 21.71 2.18 3.49E−40
Chordin-like protein 1 (Chrdl1) 7.49 19.15 1.35 2.56E−41
Thrombospondin-3 (Thbs3) 5.25 16.71 1.67 7.21E−37
Complement decay-accelerating factor, GPI-anchored (Cd55) 7.74 15.89 1.04 1.04E−10
Mitotic checkpoint serine/threonine-protein kinase BUB1 (Bub1) 7.32 14.81 1.02 4.70E−23
G1/S-specific cyclin-E2 (Ccne2) 6.42 14.00 1.12 1.48E−17
Protein MGARP (Mgarp) 4.50 12.66 1.49 1.12E−09
M-phase phosphoprotein 8 (Mphosph8) 5.78 12.46 1.11 2.24E−14
Noggin (Nog) 4.80 11.69 1.28 7.67E−10
Carbonic anhydrase 9 (Ca9) 5.45 11.63 1.09 7.97E−10
ESF1 homolog (Esf1) 5.27 11.61 1.14 1.35E−16
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl) 3.14 10.98 1.81 2.48E−25
H(+)/Cl(-) exchange transporter 3 (Clcn3) 4.15 9.18 1.15 1.12E−08
G2/M phase-specific E3 ubiquitin-protein ligase (G2e3) 3.80 7.66 1.01 2.15E−13
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (Dyrk3) 2.45 6.59 1.43 7.06E−09
Protein kinase C zeta type (Prkcz) 2.98 6.32 1.08 5.86E−07
WNT1-inducible-signaling pathway protein 3 (Wisp3) 2.82 5.89 1.06 2.27E−06
Centrosomal protein of 70 kDa (Cep70) 2.02 4.72 1.22 2.28E−08
Dermatopontin (Dpt) 1.46 3.97 1.44 3.09E−07
Murinoglobulin-1 (Mug1) 0.56 1.67 1.58 3.76E−06