Skip to main content

Table 3 List of significantly upregulated DEGs involved in cartilage formation, growth, and repair

From: Investigating the molecular control of deer antler extract on articular cartilage

Gene name

Expression level (FPKM)

log2 fold change (DAE/Blank)

p value

Blank

DAE

Hyaluronan and proteoglycan link protein 1 (Hapln1)

301.97

901.64

1.58

0

Collagen alpha-1(IX) chain (Col9a1)

142.16

519.76

1.87

0

Scrapie-responsive protein 1 (Scrg1)

203.52

491.32

1.27

1.23E−92

Cartilage oligomeric matrix protein (Comp)

230.34

490.17

1.09

0

Leukocyte cell-derived chemotaxin 1 (Cnmd)

135.34

397.34

1.55

1.08e−321

Carbonic anhydrase 2 (Ca2)

172.19

352.43

1.03

2.61E−159

Matrilin-3 (Matn3)

112.11

292.66

1.38

0

Transferrin receptor protein 1 (Tfrc)

46.77

117.84

1.33

1.65E−274

Vascular endothelial growth factor A (Vegfa)

51.06

107.19

1.07

8.57E−143

Collagen alpha-1(XXVII) chain (Col27a1)

41.63

90.66

1.12

2.44E−248

M-phase inducer phosphatase 2 (Cdc25b)

33.93

76.00

1.16

1.82E−92

Proliferation marker protein Ki-67 (Mki67)

21.76

45.38

1.06

6.36E−136

Carbonic anhydrase 12 (Ca12)

10.53

35.95

1.77

2.03E−95

Radical S-adenosyl methionine domain-containing protein 2 (Rsad2)

9.91

29.91

1.59

1.27E−69

T cell acute lymphocytic leukemia protein 1 homolog (Tal1)

10.64

23.50

1.14

2.07E−44

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (Csgalnact1)

11.15

22.80

1.03

3.03E−18

Cartilage matrix protein (Matn1)

4.78

21.71

2.18

3.49E−40

Chordin-like protein 1 (Chrdl1)

7.49

19.15

1.35

2.56E−41

Thrombospondin-3 (Thbs3)

5.25

16.71

1.67

7.21E−37

Complement decay-accelerating factor, GPI-anchored (Cd55)

7.74

15.89

1.04

1.04E−10

Mitotic checkpoint serine/threonine-protein kinase BUB1 (Bub1)

7.32

14.81

1.02

4.70E−23

G1/S-specific cyclin-E2 (Ccne2)

6.42

14.00

1.12

1.48E−17

Protein MGARP (Mgarp)

4.50

12.66

1.49

1.12E−09

M-phase phosphoprotein 8 (Mphosph8)

5.78

12.46

1.11

2.24E−14

Noggin (Nog)

4.80

11.69

1.28

7.67E−10

Carbonic anhydrase 9 (Ca9)

5.45

11.63

1.09

7.97E−10

ESF1 homolog (Esf1)

5.27

11.61

1.14

1.35E−16

Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl)

3.14

10.98

1.81

2.48E−25

H(+)/Cl(-) exchange transporter 3 (Clcn3)

4.15

9.18

1.15

1.12E−08

G2/M phase-specific E3 ubiquitin-protein ligase (G2e3)

3.80

7.66

1.01

2.15E−13

Dual specificity tyrosine-phosphorylation-regulated kinase 3 (Dyrk3)

2.45

6.59

1.43

7.06E−09

Protein kinase C zeta type (Prkcz)

2.98

6.32

1.08

5.86E−07

WNT1-inducible-signaling pathway protein 3 (Wisp3)

2.82

5.89

1.06

2.27E−06

Centrosomal protein of 70 kDa (Cep70)

2.02

4.72

1.22

2.28E−08

Dermatopontin (Dpt)

1.46

3.97

1.44

3.09E−07

Murinoglobulin-1 (Mug1)

0.56

1.67

1.58

3.76E−06