Fig. 4

miR-107 overexpression affects the expression of cartilage matrix and pyroptosis associated proteins in chondrocytes induced by LPS and ATP. a The expression of Col II, IL-1β, IL-18, and MMP-13 in chondrocytes induced by LPS and ATP was detected by western blot analysis. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control group. ^#P < 0.05 and ^###P < 0.001 vs. LPS + ATP group. ^∆P < 0.05 vs. LPS + ATP + mimic NC group. b The expression of caspase-1, c-caspase-1, GSDMD-N, and TLR4 in chondrocytes induced by LPS and ATP was detected by western blot analysis. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control group. ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 vs. LPS + ATP group. ^∆P < 0.05, ^∆∆P < 0.01, and ^∆∆∆P < 0.001 vs. LPS + ATP + mimic NC group