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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment

Fig. 6

Overexpression of miR-573 by HBO treatment blocks the mitochondrial apoptotic pathway. HBO treatment significantly down-regulated the cleaved-caspase-9 (a, b, **p < 0.01, n = 4) and cleaved-caspase-3 (a, c, **p < 0.01, n = 4) expression, whereas transfection with anti-miR-573 partly suppressed the effects of HBO treatment (b, c, ※※p < 0.01, n = 4). At the same time, HBO treatment significantly reduced the activation (cleavage) of pro-caspase 9 (a, b, **p < 0.01, n = 4) and pro-caspase 3 proteins (a, c, **p < 0.01, n = 4), whereas transfection with anti-miR-573 partly suppressed the effects of HBO (b, **p < 0.01; c, p < 0.05, n = 4) in NP cells

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