Fig. 3

Bax is a direct target of miR-573. Diagram of the binding site between miR-573 and the Bax 3′ UTR. The reporter vectors contain the wild-type (WT) or mutant (Mut) Bax 3′ UTR. Dual-luciferase reporter assay of the Bax 3′ UTR. The reporter vectors containing the WT or Mut Bax 3′ UTR were transfected into NP cells. Luciferase activity was shown to be significantly downregulated after HBO treatment (**p < 0.01; n = 4) in the constructs harboring the WT but not in the Mut 3′ UTR (p > 0.05, n = 4)