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Table 3 Incidence of potentially relevant 12-month follow-up re-admission

From: A large database study of hospitalization charges and follow-up re-admissions in US lumbar fusion surgeries using a cellular bone allograft (CBA) versus recombinant human bone morphogenetic protein-2 (rhBMP-2)

Re-admissions, n (%)[1] Full cohort Single-level only cohort
Group P value Group P value
V-CBA (n = 6588) rhBMP-2 (n = 9584) V-CBA (n = 5683) rhBMP-2 (n = 8505)
Patients with all-cause 12-month follow-up re-admissions [2] 1482 (22.5) 2021 (21.08) 971 (17.1) 1198 (14.1)
Re-admitted patients with potentially relevant procedures/diagnoses [3]
 Subsequent lumbar fusion procedures 623 (9.46) 831 (8.67) 0.0879 208 (3.66) 388 (4.56) < 0.0001*
 Cardiac complications 47 (0.71) 22 (0.23) < 0.0001^ 25 (0.44) 13 (0.15) 0.0125^
 Deep vein thrombosis 6 (0.09) 3 (0.03) 0.1725 4 (0.07) 3 (0.04) 0.7073
 Hematoma 22 (0.33) 30 (0.31) 0.8878 13 (0.23) 20 (0.23) 0.5990
 Nervous system complications 17 (0.26) 14 (0.15) 0.1422 13 (0.23) 9 (0.11) 0.1990
 Pneumonia 80 (1.21) 73 (0.76) 0.0038^ 50 (0.88) 46 (0.54) 0.1432
 Pulmonary embolism 28 (0.43) 37 (0.39) 0.706 19 (0.33) 22 (0.26) 0.8748
 Sepsis 2 (0.03) 5 (0.05) 0.7081 0 (0) 1 (0.01) 1.0000
 Surgical-site infection 15 (0.23) 20 (0.21) 0.8634 8 (0.14) 9 (0.11) 1.0000
 Urinary tract infections 144 (2.19) 171 (1.78) 0.0727 81 (1.42) 93 (1.09) 0.6341
  1. Planned analyses were conducted on the full cohort
  2. Ad hoc analyses were conducted on the single-level only cohort, which only included patients who received treatment at a single level of the spine
  3. *Statistically significant, Fisher’s exact test
  4. ^Statistically significant, Fisher’s exact test. Notably, differences observed in follow-up diagnoses between groups corresponded with significant comparisons in related initial Charlson comorbidities within each cohort (Table 1)
  5. [1]All percentages were based on the total number of patients within each cohort who received V-CBA or rhBMP-2 during the initial procedure
  6. [2]Patients with more than one re-admission were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System
  7. [3]Except subsequent lumbar fusion procedures, repeats of the same diagnosis were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System