|
Re-admissions, n (%)[1]
|
Full cohort†
|
Single-level only cohort‡
|
|---|
|
Group
|
P value
|
Group
|
P value
|
|---|
|
V-CBA (n = 6588)
|
rhBMP-2 (n = 9584)
|
V-CBA (n = 5683)
|
rhBMP-2 (n = 8505)
|
|---|
|
Patients with all-cause 12-month follow-up re-admissions [2]
|
1482 (22.5)
|
2021 (21.08)
|
–
|
971 (17.1)
|
1198 (14.1)
|
–
|
|
Re-admitted patients with potentially relevant procedures/diagnoses [3]
|
|
Subsequent lumbar fusion procedures
|
623 (9.46)
|
831 (8.67)
|
0.0879
|
208 (3.66)
|
388 (4.56)
|
< 0.0001*
|
|
Cardiac complications
|
47 (0.71)
|
22 (0.23)
|
< 0.0001^
|
25 (0.44)
|
13 (0.15)
|
0.0125^
|
|
Deep vein thrombosis
|
6 (0.09)
|
3 (0.03)
|
0.1725
|
4 (0.07)
|
3 (0.04)
|
0.7073
|
|
Hematoma
|
22 (0.33)
|
30 (0.31)
|
0.8878
|
13 (0.23)
|
20 (0.23)
|
0.5990
|
|
Nervous system complications
|
17 (0.26)
|
14 (0.15)
|
0.1422
|
13 (0.23)
|
9 (0.11)
|
0.1990
|
|
Pneumonia
|
80 (1.21)
|
73 (0.76)
|
0.0038^
|
50 (0.88)
|
46 (0.54)
|
0.1432
|
|
Pulmonary embolism
|
28 (0.43)
|
37 (0.39)
|
0.706
|
19 (0.33)
|
22 (0.26)
|
0.8748
|
|
Sepsis
|
2 (0.03)
|
5 (0.05)
|
0.7081
|
0 (0)
|
1 (0.01)
|
1.0000
|
|
Surgical-site infection
|
15 (0.23)
|
20 (0.21)
|
0.8634
|
8 (0.14)
|
9 (0.11)
|
1.0000
|
|
Urinary tract infections
|
144 (2.19)
|
171 (1.78)
|
0.0727
|
81 (1.42)
|
93 (1.09)
|
0.6341
|
- †Planned analyses were conducted on the full cohort
- ‡Ad hoc analyses were conducted on the single-level only cohort, which only included patients who received treatment at a single level of the spine
- *Statistically significant, Fisher’s exact test
- ^Statistically significant, Fisher’s exact test. Notably, differences observed in follow-up diagnoses between groups corresponded with significant comparisons in related initial Charlson comorbidities within each cohort (Table 1)
- [1]All percentages were based on the total number of patients within each cohort who received V-CBA or rhBMP-2 during the initial procedure
- [2]Patients with more than one re-admission were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System
- [3]Except subsequent lumbar fusion procedures, repeats of the same diagnosis were counted only once. Did not include patients who may have received follow-up treatment outside of the Premier Healthcare System
