Fig. 3
From: Outcome of lung metastases due to bone giant cell tumor initially managed with observation
A case of giant cell tumor of bone and lung metastases treated with denosumab rechallenge. She was referred to our institute for local recurrence following curettage and cementing for distal radius giant cell tumor of the bone. Radiograph showed osteolytic lesions (arrow) surrounding the cement (a). Chest CT showed lung metastasis in the left lung (arrow) at presentation (b). She received preoperative denosumab therapy for 4 months and radiograph showed sclerotic formation (arrow) surrounding the cement (c). She then received curettage and cementing and postoperative denosumab therapy for 1 month. However, she experienced local recurrence 14 months after the operation and underwent an en bloc resection and reconstruction with an allograft. Follow-up chest CT showed a new lesion on the right lung (arrow) 3 years after the initial operation at our institute (d). She was treated with denosumab for 1 year and the lung lesions were stable (arrows) thereafter (e)