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Table 5 Threshold effect analysis of plasma total homocysteine on lumbar bone mineral density using a two-piecewise linear regression model

From: Association between plasma total homocysteine level within normal range and bone mineral density in adults

Lumbar bone mineral density

Adjusted ß (95% CI)

Plasma total homocysteine

 

Males aged 30-49 years

 

Fitting by standard linear model

0.0018 −0.0012, 0.0048)

Fitting by two-piecewise linear model

 

Inflection point

9.0

Plasma total homocysteine <9.0 (umol/L)

0.0042 (−0.0015, 0.0099)

Plasma total homocysteine >9.0 (umol/L)

-0.0005 (−.0059, 0.0050)

Log-likelihood ratio

0.323

Males aged 50-69 years

 

Fitting by standard linear model

0.0027 (−0.0009, 0.0063)

Fitting by two-piecewise linear model

 

Inflection point

10.0

Plasma total homocysteine <10.0 (umol/L)

0.0098 (0.0032, 0.0163)

Plasma total homocysteine >10.0 (umol/L)

−0.0053 −0.0125, 0.0019)

Log-likelihood ratio

0.011

  1. Age, race, body mass index, education level, income-poverty ratio, physical activity, smoking behavior, alcohol consumption, blood urea nitrogen, total protein, total cholesterol, serum uric acid, serum folate, serum vitamin B12, serum phosphorus, and serum calcium were adjusted