Group | IV TXA | TopicalTXA | IV-combined topical TXA | OralTXA | Placebo + tourniquets | IV TXA + tourniquets | Topical TXA + tourniquets | IV-combined topical \TXA + tourniquets | P value |
---|---|---|---|---|---|---|---|---|---|
Number | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | Â |
Age(y) | 67.77 ± 5.39 | 67.37 ± 5.49 | 66.73 ± 6.15 | 66.3 ± 4.89 | 65.23 ± 6.28 | 65.73 ± 5.99 | 67.13 ± 5.56 | 65.43 ± 4.78 | 0.532 |
Gender(female/male) | 16/14 | 20/10 | 21/9 | 15/15 | 18/12 | 16/14 | 22/8 | 21/9 | 0.394 |
BMI(kg/m2) | 30.05 ± 3.02 | 30.43 ± 4.28 | 30.72 ± 2.93 | 30.54 ± 3.09 | 29.49 ± 3.87 | 29.62 ± 3.37 | 31.41 ± 3.62 | 31.33 ± 4.11 | 0.307 |
Preop.ROM(°) | 99.87 ± 8.33 | 100.01 ± 7.83 | 103.45 ± 5.35 | 101.53 ± 6.28 | 102.08 ± 6.72 | 99.37 ± 5.04 | 100.88 ± 6.98 | 102.41 ± 7.73 | 0.238 |
Surgical duration(min) | 67.60 ± 12.39 | 64.93 ± 10.79 | 68.13 ± 8.97 | 66.03 ± 12.17 | 66.07 ± 9.75 | 64.00 ± 8.53 | 63.37 ± 12.18 | 70.10 ± 11.18 | 0.256 |
Total blood loss(mL) | 1268.84 ± 342.15 | 1164.27 ± 304.19 | 653.79 ± 246.20 | 781.26 ± 213.79 | 1584.33 ± 359.21 | 1049.12 ± 266.72 | 1002.48 ± 316.29 | 739.15 ± 226.37 | <0.001 |
Transfusion | 9 | 5 | 1 | 7 | 12 | 3 | 5 | 4 | 0.009* |
Preop.Hb(g/dL) | 13.87 ± 0.66 | 13.44 ± 1.23 | 13.92 ± 1.25 | 13.89 ± 0.95 | 13.62 ± 1.02 | 13.41 ± 1.07 | 13.99 ± 1.09 | 13.47 ± 0.72 | 0.117 |
24-h Hb(g/dL) | 11.82 ± 1.04 | 11.49 ± 1.30 | 12.09 ± 1.40 | 12.74 ± 0.94 | 10.37 ± 1.26 | 11.48 ± 1.35 | 11.94 ± 1.31 | 12.11 ± 0.95 | <0.001* |
Hb change(g/dL) | 2.02 ± 0.84 | 1.95 ± 0.57 | 1.83 ± 0.61 | 1.14 ± 0.39 | 3.22 ± 1.06 | 1.93 ± 0.75 | 2.09 ± 0.61 | 1.36 ± 0.55 | <0.001* |
DVT | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0.541 |
PE | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0.432 |