Table 3 OR/WMD and 95% confidence intervals of nine treatment modalities of five end point outcomes

Control

−279.54 (−992.45, 434.18)

−308.96 (−1024.88, 426.78)

−562.67 (−1435.57, 299.48)

−394.27 (−1396.04, 632.56)

386.91 (−705.21, 1525.93)

−96.32 (−1230.91, 1077.73)

−28.850 (−1195.33, 1191.28)

−469.22 (−1572.29, 634.08)

279.54 (−434.18, 992.45)

IV

−28.22 (−734.22, 662.79)

−282.77 (−780.12, 207.94)

−115.28 (−1079.06, 870.79)

671.39 (−195.64, 1524.22)

186.49 (−707.88, 1110.99)

252.16 (−687.87, 1212.63)

−179.78 (−1068.64, 682.97)

308.96 (−426.78, 1024.88)

28.22 (−662.79, 734.22)

Topical

−245.88 (−1105.28, 602.53)

−79.97 (−777.45, 615.71)

697.78 (−380.83, 1813.94)

214.28 (−906.59, 1355.67)

283.58 (−876.70, 1470.69)

−147.79 (−1272.04, 918.77)

562.67 (−299.48, 1435.57)

282.77 (−207.94, 780.12)

245.88 (−602.53, 1105.28)

IV + Topical

165.30 (−912.01, 1256.91)

954.88 (266.02, 1654.51)

471.25 (−273.91, 1238.80)

540.05 (−273.34, 1359.22)

107.35 (−602.64, 788.28)

394.27 (−632.56, 1396.04)

115.28 (−870.79, 1079.06)

79.97 (−615.71, 777.45)

−165.30 (−1256.91, 912.01)

Oral

784.26 (−507.66, 2069.12)

304.93 (−1045.00, 1636.16)

373.44 (−989.60, 1741.73)

−62.52 (−1380.86, 1215.63)

−386.91 (−1525.93, 705.21)

−671.39 (−1524.22, 195.64)

−697.78 (−1813.94, 380.83)

−954.88 (−1654.51, −266.02)

−784.26 (−2069.12, 507.66)

T

−482.09 (−768.30, −195.69)

−410.97 (−828.87, −3.30)

−850.19 (−1568.81, −151.31)

96.32 (−1077.73, 1230.91)

−186.49 (−1110.99, 707.88)

−214.28 (−1355.67, 906.59)

−471.25 (−1238.80, 273.91)

−304.93 (−1636.16, 1045.00)

482.09 (195.69, 768.30)

IV + T

70.28 (−314.39, 455.56)

−372.67 (−1148.75, 370.06)

28.85 (−1191.28, 1195.33)

−252.16 (−1212.63, 687.87)

−283.58 (−1470.69, 876.70)

−540.05 (−1359.22, 273.34)

−373.44 (−1741.73, 989.60)

410.97 (3.30, 828.87)

−70.28 (−455.56, 314.39)

−441.48 (−1268.95, 369.63)

469.22 (−634.08, 1572.29)

179.78 (−682.97, 1068.64)

147.79 (−918.77, 1272.04)

−107.35 (−788.28, 602.64)

62.52 (−1215.63, 1380.86)

850.19 (151.31, 1568.81)

372.67 (−370.06, 1148.75)

441.48 (−369.63, 1268.95)

Control

0.23 (0.02, 2.03)

0.36 (0.04, 2.88)

0.04 (0.00, 1.45)

0.27 (0.01, 5.87)

—>100 (31.61, —>100)

—>100 (3.78,—>100)

—>100 (6.98, —>100)

0.00 (0.00,—>100 )

4.40 (0.49, 43.87)

IV

1.51 (0.17, 16.26)

0.17 (0.00, 2.92)

1.07 (0.04, 28.47)

—>100 (—>100, —>100)

—>100 (23.94,—>100)

—>100 (41.90, —>100)

0.00 (0.00,—>100 )

2.80 (0.35, 25.73)

0.66 (0.06, 5.82)

Topical

0.11 (0.00, 3.93)

0.75 (0.06, 7.87)

—>100 (87.19, —>100)

—>100 (9.74,—>100)

—>100 (16.69, —>100)

0.00 (0.00,—>100 )

26.89 (0.69, 5597.56)

5.85 (0.34, 769.88)

9.17 (0.25, 1741.44)

IV + Topical

6.41 (0.08, 1831.07)

—>100 (—>100, —>100)

—>100 (281.87,—>100)

—>100 (500.86, —>100)

0.00 (0.00,—>100 )

3.74 (0.17, 107.08)

0.94 (0.04, 24.79)

1.33 (0.13, 17.90)

0.16 (0.00, 12.87)

Oral

—>100 (75.55, —>100)

—>100 (6.85, —>100)

—>100 (12.70, —>100)

0.00 (0.00,—>100 )

0.00 (0.00, 0.03)

0.00 (0.00, 0.01)

0.00 (0.00, 0.01)

0.00 (0.00, 0.00)

0.00 (0.00, 0.01)

T

0.07 (0.02, 0.18)

0.16 (0.04, 0.48)

0.00 (0.00, 0.02)

0.00 (0.00, 0.26)

0.00 (0.00, 0.04)

0.00 (0.00, 0.10)

0.00 (0.00, 0.00)

0.00 (0.00, 0.15)

14.15 (5.45, 50.16)

IV + T

2.24 (0.62, 9.67)

0.00 (0.00, 0.31)

0.00 (0.00, 0.14)

0.00 (0.00, 0.02)

0.00 (0.00, 0.06)

0.00 (0.00, 0.00)

0.00 (0.00, 0.08)

6.31 (2.10, 22.26)

0.45 (0.10, 1.63)

Topical + T

0.00 (0.00, 0.10)

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (0.00, —>100)

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (52.32, —>100)

—>100 (3.27, —>100)

—>100 (9.66, —>100)

IV + Topical + T

Control

1.19 (−2.48, 4.69)

1.43 (−2.08, 4.96)

1.82 (−2.59, 6.14)

1.66 (−3.16, 6.52)

0.19 (−5.43, 5.95)

2.32 (−3.71, 8.35)

2.39 (−3.86, 8.41)

1.65 (−4.10, 7.16)

−1.19 (−4.69, 2.48)

IV

0.27 (−3.29, 3.84)

0.66 (−1.81, 3.21)

0.46 (−4.42, 5.67)

−0.97 (−5.28, 3.45)

1.14 (−3.52, 6.03)

1.21 (−3.70, 6.13)

0.45 (−3.79, 4.84)

−1.43 (−4.96, 2.08)

−0.27 (−3.84, 3.29)

Topical

0.38 (−4.04, 4.76)

0.21 (−3.14, 3.66)

−1.23 (−6.82, 4.38)

0.92 (−5.10, 6.92)

0.97 (−5.24, 6.89)

0.21 (−5.44, 5.76)

−1.82 (−6.14, 2.59)

−0.66 (−3.21, 1.81)

−0.38 (−4.76, 4.04)

IV + Topical

−0.16 (−5.73, 5.46)

−1.61 (−5.18, 1.86)

0.52 (−3.55, 4.49)

0.58 (−3.76, 4.61)

−0.20 (−3.69, 3.26)

−1.66 (−6.52, 3.16)

−0.46 (−5.67, 4.42)

−0.21 (−3.66, 3.14)

0.16 (−5.46, 5.73)

Oral

−1.42 (-8.13, 5.12)

0.70 (-6.26, 7.59)

0.78 (−6.51, 7.58)

−0.02 (−6.84, 6.43)

−0.19 (−5.95, 5.43)

0.97 (−3.45, 5.28)

1.23 (−4.38, 6.82)

1.61 (−1.86, 5.18)

1.42 (−5.12, 8.13)

T

2.15 (0.17, 4.06)

2.18 (−0.22, 4.33)

1.42 (−2.07, 4.87)

−2.32 (−8.35, 3.71)

−1.14 (−6.03, 3.52)

−0.92 (−6.92, 5.10)

-0.52 (−4.49, 3.55)

−0.70 (−7.59, 6.26)

−2.15 (−4.06, −0.17)

IV + T

0.03 (−1.78, 1.73)

−0.73 (−4.67, 3.27)

−2.39 (−8.41, 3.86)

−1.21 (−6.13, 3.70)

−0.97 (−6.89, 5.24)

−0.58 (−4.61, 3.76)

−0.78 (−7.58, 6.51)

−2.18 (−4.33, 0.22)

−.03 (−1.73, 1.78)

Topical + T

−0.76 (−4.73, 3.45)

−1.65 (−7.16, 4.10)

−0.45 (−4.84, 3.79)

−0.21 (−5.76, 5.44)

0.20 (−3.26, 3.69)

0.02 (−6.43, 6.84)

−1.42 (−4.87, 2.07)

0.73 (−3.27, 4.67)

0.76 (−3.45, 4.73)

IV

0.00 (0.00, 3.45)

0.00 (0.00,—>100)

0.00 (0.00,—>100)

0.00 (0.00,—>100)

0.00 (0.00,—>100)

—>100 (0.29, —>100 )

IV + Topical

0.07 (0.00, —>100)

0.04 (0.00, —>100 )

0.16 (0.00, —>100 )

0.01 (0.00, —>100 )

—>100 (0.00,—>100)

14.38 (0.00, —>100 )

T

0.72 (0.11, 3.67)

2.03 (0.09, 47.51)

7.54 (0.00,—>100 )

—>100 (0.00,—>100)

24.63 (0.00, —>100 )

1.39 (0.27, 9.28)

IV + T

2.75 (0.09, 116.04)

6.40 (0.00, —>100 )

—>100 (0.00,—>100)

6.18 (0.00, —>100 )

0.49 (0.02, 11.22)

0.36 (0.01, 11.57)

Topical + T

1.79 (0.00, —>100 )

—>100 (0.00,—>100)

93.11 (0.00, —>100 )

0.13 (0.00,—>100 )

0.16 (0.00, —>100 )

0.56 (0.00,—>100 )

IV + Topical + T

IV

1.06 (0.01, 96.80)

0.09 (0.00, —>100)

0.00 (0.00,—>100)

0.00 (0.00,—>100)

0.01 (0.00, —>100)

0.94 (0.01, 67.85)

IV + Topical

0.08 (0.00, —>100)

0.00 (0.00,—>100)

0.00 (0.00,—>100)

0.01 (0.00,—>100)

10.78 (0.00, —>100)

12.88 (0.00, —>100)

T

0.00 (0.00, 0.26)

0.00 (0.00, 0.21)

0.01 (0.00, —>100 )

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (3.84,—>100)

IV + T

0.47 (0.01, 13.69)

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (4.82, —>100)

2.13 (0.07, 81.42)

Topical + T

—>100 (0.00,—>100)

—>100 (0.00,—>100)

—>100 (0.00,—>100)

71.96 (0.00,—>100)

—>100 (0.00,—>100)

0.00 (0.00,—>100 )

IV + Topical + T