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Table 3 OR/WMD and 95% confidence intervals of nine treatment modalities of five end point outcomes

From: Hemostatic effect of tourniquet combined with tranexamic acid in total knee arthroplasty: a network meta-analysis

OR/WMD(95%CI)
The total blood loss
Control −279.54 (−992.45, 434.18) −308.96 (−1024.88, 426.78) −562.67 (−1435.57, 299.48) −394.27 (−1396.04, 632.56) 386.91 (−705.21, 1525.93) −96.32 (−1230.91, 1077.73) −28.850 (−1195.33, 1191.28) −469.22 (−1572.29, 634.08)
279.54 (−434.18, 992.45) IV −28.22 (−734.22, 662.79) −282.77 (−780.12, 207.94) −115.28 (−1079.06, 870.79) 671.39 (−195.64, 1524.22) 186.49 (−707.88, 1110.99) 252.16 (−687.87, 1212.63) −179.78 (−1068.64, 682.97)
308.96 (−426.78, 1024.88) 28.22 (−662.79, 734.22) Topical −245.88 (−1105.28, 602.53) −79.97 (−777.45, 615.71) 697.78 (−380.83, 1813.94) 214.28 (−906.59, 1355.67) 283.58 (−876.70, 1470.69) −147.79 (−1272.04, 918.77)
562.67 (−299.48, 1435.57) 282.77 (−207.94, 780.12) 245.88 (−602.53, 1105.28) IV + Topical 165.30 (−912.01, 1256.91) 954.88 (266.02, 1654.51) 471.25 (−273.91, 1238.80) 540.05 (−273.34, 1359.22) 107.35 (−602.64, 788.28)
394.27 (−632.56, 1396.04) 115.28 (−870.79, 1079.06) 79.97 (−615.71, 777.45) −165.30 (−1256.91, 912.01) Oral 784.26 (−507.66, 2069.12) 304.93 (−1045.00, 1636.16) 373.44 (−989.60, 1741.73) −62.52 (−1380.86, 1215.63)
−386.91 (−1525.93, 705.21) −671.39 (−1524.22, 195.64) −697.78 (−1813.94, 380.83) −954.88 (−1654.51, −266.02) −784.26 (−2069.12, 507.66) T −482.09 (−768.30, −195.69) −410.97 (−828.87, −3.30) −850.19 (−1568.81, −151.31)
96.32 (−1077.73, 1230.91) −186.49 (−1110.99, 707.88) −214.28 (−1355.67, 906.59) −471.25 (−1238.80, 273.91) −304.93 (−1636.16, 1045.00) 482.09 (195.69, 768.30) IV + T 70.28 (−314.39, 455.56) −372.67 (−1148.75, 370.06)
28.85 (−1191.28, 1195.33) −252.16 (−1212.63, 687.87) −283.58 (−1470.69, 876.70) −540.05 (−1359.22, 273.34) −373.44 (−1741.73, 989.60) 410.97 (3.30, 828.87) −70.28 (−455.56, 314.39) Topical+T −441.48 (−1268.95, 369.63)
469.22 (−634.08, 1572.29) 179.78 (−682.97, 1068.64) 147.79 (−918.77, 1272.04) −107.35 (−788.28, 602.64) 62.52 (−1215.63, 1380.86) 850.19 (151.31, 1568.81) 372.67 (−370.06, 1148.75) 441.48 (−369.63, 1268.95) IV + Topical+T
Transfusion
Control 0.23 (0.02, 2.03) 0.36 (0.04, 2.88) 0.04 (0.00, 1.45) 0.27 (0.01, 5.87) —>100 (31.61, —>100) —>100 (3.78,—>100) —>100 (6.98, —>100) 0.00 (0.00,—>100 )
4.40 (0.49, 43.87) IV 1.51 (0.17, 16.26) 0.17 (0.00, 2.92) 1.07 (0.04, 28.47) —>100 (—>100, —>100) —>100 (23.94,—>100) —>100 (41.90, —>100) 0.00 (0.00,—>100 )
2.80 (0.35, 25.73) 0.66 (0.06, 5.82) Topical 0.11 (0.00, 3.93) 0.75 (0.06, 7.87) —>100 (87.19, —>100) —>100 (9.74,—>100) —>100 (16.69, —>100) 0.00 (0.00,—>100 )
26.89 (0.69, 5597.56) 5.85 (0.34, 769.88) 9.17 (0.25, 1741.44) IV + Topical 6.41 (0.08, 1831.07) —>100 (—>100, —>100) —>100 (281.87,—>100) —>100 (500.86, —>100) 0.00 (0.00,—>100 )
3.74 (0.17, 107.08) 0.94 (0.04, 24.79) 1.33 (0.13, 17.90) 0.16 (0.00, 12.87) Oral —>100 (75.55, —>100) —>100 (6.85, —>100) —>100 (12.70, —>100) 0.00 (0.00,—>100 )
0.00 (0.00, 0.03) 0.00 (0.00, 0.01) 0.00 (0.00, 0.01) 0.00 (0.00, 0.00) 0.00 (0.00, 0.01) T 0.07 (0.02, 0.18) 0.16 (0.04, 0.48) 0.00 (0.00, 0.02)
0.00 (0.00, 0.26) 0.00 (0.00, 0.04) 0.00 (0.00, 0.10) 0.00 (0.00, 0.00) 0.00 (0.00, 0.15) 14.15 (5.45, 50.16) IV + T 2.24 (0.62, 9.67) 0.00 (0.00, 0.31)
0.00 (0.00, 0.14) 0.00 (0.00, 0.02) 0.00 (0.00, 0.06) 0.00 (0.00, 0.00) 0.00 (0.00, 0.08) 6.31 (2.10, 22.26) 0.45 (0.10, 1.63) Topical + T 0.00 (0.00, 0.10)
—>100 (0.00,—>100) —>100 (0.00,—>100) —>100 (0.00, —>100) —>100 (0.00,—>100) —>100 (0.00,—>100) —>100 (52.32, —>100) —>100 (3.27, —>100) —>100 (9.66, —>100) IV + Topical + T
Change of Hb
Control 1.19 (−2.48, 4.69) 1.43 (−2.08, 4.96) 1.82 (−2.59, 6.14) 1.66 (−3.16, 6.52) 0.19 (−5.43, 5.95) 2.32 (−3.71, 8.35) 2.39 (−3.86, 8.41) 1.65 (−4.10, 7.16)
−1.19 (−4.69, 2.48) IV 0.27 (−3.29, 3.84) 0.66 (−1.81, 3.21) 0.46 (−4.42, 5.67) −0.97 (−5.28, 3.45) 1.14 (−3.52, 6.03) 1.21 (−3.70, 6.13) 0.45 (−3.79, 4.84)
−1.43 (−4.96, 2.08) −0.27 (−3.84, 3.29) Topical 0.38 (−4.04, 4.76) 0.21 (−3.14, 3.66) −1.23 (−6.82, 4.38) 0.92 (−5.10, 6.92) 0.97 (−5.24, 6.89) 0.21 (−5.44, 5.76)
−1.82 (−6.14, 2.59) −0.66 (−3.21, 1.81) −0.38 (−4.76, 4.04) IV + Topical −0.16 (−5.73, 5.46) −1.61 (−5.18, 1.86) 0.52 (−3.55, 4.49) 0.58 (−3.76, 4.61) −0.20 (−3.69, 3.26)
−1.66 (−6.52, 3.16) −0.46 (−5.67, 4.42) −0.21 (−3.66, 3.14) 0.16 (−5.46, 5.73) Oral −1.42 (-8.13, 5.12) 0.70 (-6.26, 7.59) 0.78 (−6.51, 7.58) −0.02 (−6.84, 6.43)
−0.19 (−5.95, 5.43) 0.97 (−3.45, 5.28) 1.23 (−4.38, 6.82) 1.61 (−1.86, 5.18) 1.42 (−5.12, 8.13) T 2.15 (0.17, 4.06) 2.18 (−0.22, 4.33) 1.42 (−2.07, 4.87)
−2.32 (−8.35, 3.71) −1.14 (−6.03, 3.52) −0.92 (−6.92, 5.10) -0.52 (−4.49, 3.55) −0.70 (−7.59, 6.26) −2.15 (−4.06, −0.17) IV + T 0.03 (−1.78, 1.73) −0.73 (−4.67, 3.27)
−2.39 (−8.41, 3.86) −1.21 (−6.13, 3.70) −0.97 (−6.89, 5.24) −0.58 (−4.61, 3.76) −0.78 (−7.58, 6.51) −2.18 (−4.33, 0.22) −.03 (−1.73, 1.78) Topical + T −0.76 (−4.73, 3.45)
−1.65 (−7.16, 4.10) −0.45 (−4.84, 3.79) −0.21 (−5.76, 5.44) 0.20 (−3.26, 3.69) 0.02 (−6.43, 6.84) −1.42 (−4.87, 2.07) 0.73 (−3.27, 4.67) 0.76 (−3.45, 4.73)  
DVT
IV 0.00 (0.00, 3.45) 0.00 (0.00,—>100) 0.00 (0.00,—>100) 0.00 (0.00,—>100) 0.00 (0.00,—>100)  
—>100 (0.29, —>100 ) IV + Topical 0.07 (0.00, —>100) 0.04 (0.00, —>100 ) 0.16 (0.00, —>100 ) 0.01 (0.00, —>100 )
—>100 (0.00,—>100) 14.38 (0.00, —>100 ) T 0.72 (0.11, 3.67) 2.03 (0.09, 47.51) 7.54 (0.00,—>100 )
—>100 (0.00,—>100) 24.63 (0.00, —>100 ) 1.39 (0.27, 9.28) IV + T 2.75 (0.09, 116.04) 6.40 (0.00, —>100 )
—>100 (0.00,—>100) 6.18 (0.00, —>100 ) 0.49 (0.02, 11.22) 0.36 (0.01, 11.57) Topical + T 1.79 (0.00, —>100 )
—>100 (0.00,—>100) 93.11 (0.00, —>100 ) 0.13 (0.00,—>100 ) 0.16 (0.00, —>100 ) 0.56 (0.00,—>100 ) IV + Topical + T
PE
IV 1.06 (0.01, 96.80) 0.09 (0.00, —>100) 0.00 (0.00,—>100) 0.00 (0.00,—>100) 0.01 (0.00, —>100)  
0.94 (0.01, 67.85) IV + Topical 0.08 (0.00, —>100) 0.00 (0.00,—>100) 0.00 (0.00,—>100) 0.01 (0.00,—>100)
10.78 (0.00, —>100) 12.88 (0.00, —>100) T 0.00 (0.00, 0.26) 0.00 (0.00, 0.21) 0.01 (0.00, —>100 )
—>100 (0.00,—>100) —>100 (0.00,—>100) —>100 (3.84,—>100) IV + T 0.47 (0.01, 13.69) —>100 (0.00,—>100)
—>100 (0.00,—>100) —>100 (0.00,—>100) —>100 (4.82, —>100) 2.13 (0.07, 81.42) Topical + T —>100 (0.00,—>100)
—>100 (0.00,—>100) —>100 (0.00,—>100) 71.96 (0.00,—>100) —>100 (0.00,—>100) 0.00 (0.00,—>100 ) IV + Topical + T
  1. Notes: Hb hemoglobin, DVT deep vein thrombosis, PE pulmonary embolism; Control = Placebo; IV=IV TXA; Topical = topical TXA; IV + Topical = IV combined topical TXA; Oral = Oral TXA; T = Placebo+tourniquets; IV + T = IV TXA + tourniquets; Topical+T = topical TXA + tourniquets; IV + Topical+T = IV-combined topical TXA + tourniquets; .—>100 = Far more than 100
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X