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Table 1 General information of included studies

From: Disordered leptin and ghrelin bioactivity in adolescent idiopathic scoliosis (AIS): a systematic review and meta-analysis

Author (year) Country Age (year) (AIS/control) BMI (kg/m2) (AIS/control) No of case (AIS/control) Leptin (ng/ml) (AIS/Control) sOB-R (ng/ml) (AIS/Control) Free leptin index (Leptin/sOB-R) (AIS/Control) Ghrelin (pg/ml) (AIS/control) Detection method
Qiu et al. 2007 [11] China 13.5/15.1 17.5 ± 0.2/20.9 ± 0.4 47/80 8.6 ± 0.8/14.9 ± 0.9     ELISA
Liu et al. 2012 [12] China 13.7 ± 1.5/13.8 ± 1.4 17.8 ± 2.3/19.5 ± 2.2 95/46 7.0 ± 5.0/8.4 ± 5.8 23.7 ± 6.7/20.5 ± 5.6 0.33 ± 0.25/0.48 ± 0.41   ELISA
Clark 2014 [23] UK None 17.2 ± 2.9/17.6 ± 2.8 180/3152 5.24 ± 4.26/6.28 ± 5.11     ELISA
Tam et al. 2014 [18] China 13.05 ± 0.52/12.93 ± 0.43 17.91 ± 2.20/18.64 ± 2.15 94/87 6.75 ± 5.01/7.26 ± 4.99 25.86 ± 6.49/23.43 ± 5.27    ELISA
Tam et al. 2016 [19] China 12.91 ± 0.63/12.96 ± 0.45 17.59 ± 2.10/18.35 ± 2.23 148/116 8.1 ± 7.48/10.47 ± 8.34 26.46 ± 6.66/23.98 ± 6.95 0.28/0.39   ELISA
Wang et al. 2016 [17] China 12.81 ± 1.82/13.67 ± 1.67 17.66 ± 1.15/19.66 ± 0.91 31/15 7.62 ± 2.80/8.89 ± 4.15     ELISA
Yu et al. 2018 [20] China 12.43 ± 1.90/12.80 ± 1.22 17.83 ± 1.18/17.55 ± 1.35 105/40 6.55 ± 2.88/8.01 ± 3.12    6550 ± 2460/4460 ± 2020 ELISA
Gauzy et al. 2015 [22] France 14.3 ± 1.4/13.9 ± 1.6 19.1 ± 2.6/18.5 ± 2.5 49/15     261.9 ± 120.3/146.1 ± 59.2 Radioimmunoassay
Xiao et al. 2020 [21] China 14.52 ± 2.24/14.23 ± 2.04 17.76 ± 2.60/20.87 ± 4.54 83/44     27.33 ± 6.57/15.81 ± 3.82 ELISA
  1. ELISA enzyme-linked immunosorbent assay