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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Identification of potential specific biomarkers and key signaling pathways between osteogenic and adipogenic differentiation of hBMSCs for osteoporosis therapy

Fig. 5

Key genes analysis in the AD. a–c Network representation of the protein-protein interactions (PPI) between the top 20 genes of the DEGs in different time points in the AD by the Between mode using cytoHubba app in the Cytoscape. The node’s colors donated the clustering coefficient, and the brighter the color, the higher the clustering, which meant stronger interaction (range from red (high) to yellow (low)), while the size of each node represented node degree distribution. d–f PPI visualization of networks with the DEGs enriched in the hub pathway (Rap1 signaling pathway) of the AD, the color, and size of each point meant as the same meaning as above. a, d 2d vs 0d; b, e 3d vs 0d; c, f 4d vs 0d

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