Serum globulin and albumin to globulin ratio as potential diagnostic biomarkers for periprosthetic joint infection: a retrospective review

Table 3 The diagnostic performances of serum proteins in detecting PJI

	TP	ALB	GLB	A/G ratio
AUC	0.678	0.608	0.770	0.779
95% CI	0.589–0.758	0.517–0.693	0.687–0.840	0.697–0.848
P value	< 0.001	0.053	< 0.001	< 0.001
Threshold	66.4	37.3	29.8	1.2
Sensitivity (%)	86.84	42.11	78.95	65.79
Specificity (%)	47.19	78.65	69.66	78.65
PPV (%)	41.3	45.7	52.6	56.8
NPV (%)	89.4	76.1	88.6	84.3
+LR	1.64	1.97	2.60	3.08
−LR	0.28	0.74	0.30	0.43
Accuracy (%)	59.05	67.72	72.44	74.80
DOR	5.90	2.68	8.61	7.08

PJI periprosthetic joint infection, TP total protein, ALB albumin, GLB globulin, A/G albumin to globulin, CI confidence interval, AUC area under the curve, PPV positive predictive value, NPV negative predictive value, +LR positive likelihood ratio, −LR negative likelihood ratio, DOR diagnose odds ratio

ISSN: 1749-799X