Fig. 5

Silencing of RGMA suppresses STAT3 signaling pathway to promote the locomotor function recovery in SCI rats. a Weekly locomotor function of rats evaluated using the BBB rating scale. b Coordination of rat hindlimbs measured by a ladder-climbing test. c Total protein and phosphorylation of STAT3 in gray matter measured by western blot analysis. N = 8. Data were presented as mean ± SD from at least three independent experiments. Data were compared by one-way or two-way ANOVA. *p < 0.05 vs sh-NC; ^#p < 0.05 vs sh-RGMA + NC inhibitor