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Table 1 The top 10 upregulated and downregulated DEGs

From: Analysis of key genes and pathways associated with the pathogenesis of intervertebral disc degeneration

Group

Gene symbol

logFC

P value

Downregulated

DMKN

− 3.168

0.006602318

LOC647070

− 3.042

0.001467741

GSK3A

− 2.233

0.005937805

FLJ32214

− 2.113

0.023887151

ATP13A1

− 1.831

0.008133858

RAB11B

− 1.702

0.001118076

ZNF808

− 1.525

0.045232746

USP28

− 1.478

0.015404176

LOC642533

− 1.458

0.019098623

LOC222070

− 1.403

0.03768916

Upregulated

LUM

3.147

0.018330652

HTRA1

2.435

0.031358097

SPARC

2.320

0.032710624

RPLP0

2.275

0.03908414

KIAA1751

2.184

0.026912864

CLU

2.030

0.027190866

ND2

1.991

0.046653239

COL3A1

1.949

0.015460576

S100A4

1.937

0.021301645

MXRA5

1.877

0.020244629