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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model

Fig. 7

WT mice have significantly increased collagen type I expression in the tendon adhesions. Representative images of collagen type I expression (gold) in the tendon adhesions of WT (a-b) and FliiTg/Tg (e-f) mice and collagen type III expression (gold) in the tendon adhesions of WT (c-d) FliiTg/Tg (g-h) at 21 and 28 days post 50% partial laceration injury. (i) WT mice have significantly upregulated collagen type I levels in the adhesions compared with FliiTg/Tg mice. (j) No significant difference was noted in collagen type III levels in WT and FliiTg/Tg mice, although detectable levels of collagen type III were found in the FliiTg/Tg mice. DAPI is represented as blue fluorescence; t, tendon; d, dermis. Dotted line represents tendon adhesion area. Magnification × 10. Scale bar = 200 μM and refers to all images. Data represented as mean ± SEM. *p ≤ 0.05. n = 6

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