Table 3 Subgroup analysis of parallel and series tests for PJI diagnosis
Diagnostic method | Number of studies | Sen (95% CI) | Spe (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|---|
IL-6 + CRP (Series and parallel) | 10 | 0.84 (0.80−0.88) | 0.85 (0.82–0.88) | 5.98 (3.24−11.01) | 0.17 (0.07−0.39) | 58.35 (18.04−188.79) | 0.9453 |
IL-6 | 8 | 0.87 (0.82−0.90) | 0.83 (0.79−0.87) | 4.95 (3.19−7.68) | 0.16 (0.07−0.38) | 36.27 (12.67−103.88) | 0.9237 |
CRP | 8 | 0.84 (0.79−0.88) | 0.83 (0.79−0.87) | 4.97 (3.03−8.17) | 0.21 (0.12−0.36) | 27.24 (10.61−69.91) | 0.9074 |
IL-6 + CRP (Parallel) | 5 | 0.94 (0.90−0.97) | 0.74 (0.69−0.79) | 3.67 (2.06−6.53) | 0.05 (0.01−0.31) | 79.52 (11.18−565.82) | 0.9563 |
IL-6 | 5 | 0.89 (0.84−0.93) | 0.79 (0.74−0.84) | 4.28 (2.46−7.45) | 0.12 (0.04−0.33) | 43.55 (9.41−201.58) | 0.9327 |
CRP | 5 | 0.84 (0.78−0.88) | 0.85 (0.80−0.89) | 5.32 (2.76−10.25) | 0.19 (0.09−0.39) | 32.67 (8.91−119.81) | 0.9180 |
IL-6 + CRP (Series) | 5 | 0.66 (0.57−0.74) | 0.96 (0.92−0.98) | 14.26 (4.05−50.24) | 0.34 (0.15−0.76) | 53.94 (8.45−344.35) | 0.9421 |
IL-6 | 5 | 0.86 (0.79−0.91) | 0.83 (0.78−0.88) | 4.55 (2.82−7.35) | 0.19 (0.06−0.66) | 26.49 (8.30−84.55) | 0.9056 |
CRP | 5 | 0.77 (0.69−0.84) | 0.80 (0.75−0.85) | 3.85 (2.25−6.57) | 0.31 (0.20−0.50) | 13.28 (5.19−34) | 0.8537 |