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Table 3 Patient and implant characteristics including date of implantation and implant type, allergy history, symptoms, patch test results, timing of allergy work-up and revision surgery, and change in KOOS scores (CoCroMo incl. Ni+, cobalt-chromium-molybdenum alloy includes up to 1% nickel; AA, allergic asthma; AR, allergic rhinitis; FA, family history of atopy; AE, atopic eczema; ARM, self-reported intolerance reactions to metallic objects; JP, joint pain; Sw, swelling; Er, localized erythema; Ec, localized eczema; JE, joint effusion; LA, limited ambulation; Genta, gentamicin; Ni, nickel; BPO, benzoyl peroxide)

From: The role of antibiotic-loaded bone cement in complicated knee arthroplasty: relevance of gentamicin allergy and benefit from revision surgery — a case control follow-up study and algorithmic approach

ID Implantation Manufacturer:
model
Alloy Allergy
history
Symptoms Patch
test
JR→WU
JR→RS
§
WU→FU
£
KOOS
Diff ‡
1 Apr 04, 2008 Zimmer:
Protasul
CoCroMo
(incl. Ni+)
none JP, Sw, JE, LA Genta 28 33 56 + 62.1
2 Apr 09, 2009 DePuy:
LCS
CoCroMo
(incl. Ni+)
FA JP, LA Genta 19 22 54 + 18.9
3 Apr 22, 2010 Smith and Nephew:
Genesis II
CoCroMo
(incl. Ni+)
FA JP, Sw, JE, LA Genta 11 15 52 + 07.6
4 Jul 02, 2010 DePuy:
PFC
CoCroMo
(incl. Ni+)
FA JP, Sw, JE, LA Genta 13 17 45 + 68.9
5 Apr 12, 2011 DePuy:
PFC
CoCroMo
(incl. Ni+)
AR, ARM JP, Sw, Er, Ec, LA Genta 4 no rev 45 + 11.3
6 Mar 28, 2010 Biomet Oxford:
Vanguard
CoCroMo
(incl. Ni+)
AR, AA, AE Sw, JE Genta 19 no rev 43 − 04.6
7 Jan 21, 2011 Zimmer:
INNEX
CoCroMo
(incl. Ni+)
none JP, Sw, LA Genta 14 18 37 + 33.4
8 Feb 28, 2011 DePuy:
PFC
CoCroMo
(incl. Ni+)
none JP, Sw Genta 13 17 37 + 19.2
9 Feb 18, 2011 DePuy:
PFC
CoCroMo
(incl. Ni+)
none Sw, LA Genta 16 no rev 35 + 01.5
10 Aug 06, 2009 Endoplant:
Solution EPP
CoCroMo
(incl. Ni+)
AR, AA, AE, FA JP, Sw, LA Genta 35 38 33 − 14.4
11 Sep 16, 2011 DePuy:
PFC
CoCroMo
(incl. Ni+)
none JP, Ec, JE, LA Genta, BPO 13 no rev 31 + 03.8
12 Sep 09, 2008 DePuy:
LCS
CoCroMo
(incl. Ni+)
AR, ARM, FA JP, Sw, LA Ni, Genta 53 no rev 26 + 56.0
13 Aug 20, 2012 Stryker:
Triathlon
CoCroMo
(incl. Ni+)
ARM JP, Ec, JE, LA Genta 6 no rev 26 + 28.8
14 Aug 26, 2011 Zimmer:
INNEX
CoCroMo
(incl. Ni+)
FA JP, Sw, JE, LA Genta 19 27 25 + 03.7
15 Jun 06, 2012 Zimmer:
Nexgen
CoCroMo
(incl. Ni+)
ARM JP, Sw, JE, LA Ni, Genta 12 15 23 + 16.7
  1. †Interval between primary implantation of joint replacement (JR) and allergy work-up (WU) in months
  2. §Interval between primary implantation of joint replacement (JR) and revision surgery (RS) in months
  3. £Interval between allergy work-up (WU) and follow-up (FU) in months
  4. ‡Individual KOOS index difference (absolute change)