Table 3 Subgroup analysis of D-dimer for PJI diagnosis
From: Diagnostic accuracy of D-dimer in periprosthetic joint infection: a diagnostic meta-analysis
Subgroup analyses | No. of studies | Sensitivity (95% CI) | Specificity (95% CI) | PLN (95% CI) | NLR (95% CI) | AUC (95% CI) | Diagnostic score (95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|---|
Overall studies | 9 | 0.82 (0.72–0.89) | 0.73 (0.58–0.83) | 2.99 (1.84–4.88) | 0.25 (0.15–0.41) | 0.85 (0.82–0.88) | 2.50 (1.61–3.40) | 12.20 (4.98–29.86) |
Study design | ||||||||
Retrospective | 5 | 0.80 (0.63–0.90) | 0.65 (0.45–0.81) | 2.27 (1.35–3.84) | 0.31 (0.17–0.59) | 0.80 (0.76–0.83) | 1.98 (0.99–2.97) | 7.24 (2.68–19.53) |
Prospective | 4 | 0.86 (0.75–0.92) | 0.80 (0.65–0.90) | 4.34 (2.22–8.49) | 0.18 (0.09–0.34) | 0.90 (0.87–0.93) | 3.19 (1.96–4.43) | 24.39 (7.12–83.52) |
Cutoff value | ||||||||
850 ng/ml | 4 | 0.85 (0.69–0.93) | 0.69 (0.43–0.86) | 2.71 (1.40–5.27) | 0.22 (0.11–0.44) | 0.85 (0.82–0.88) | 2.50 (1.52–3.48) | 12.14 (4.56–32.31) |
Other | 5 | 0.81 (0.68–0.89) | 0.76 (0.60–0.87) | 3.30 (1.71–6.36) | 0.25 (0.13–0.51) | 0.85 (0.82–0.88) | 2.57 (1.25–3.88) | 13.00 (3.49–48.46) |
Sample size | ||||||||
> 110 | 5 | 0.85 (0.70–0.94) | 0.67 (0.44–0.84) | 2.57 (1.33–4.98) | 0.22 (0.09–0.52) | 0.85 (0.81–0.88) | 2.46 (1.10–3.81) | 11.65 (3.00–45.26) |
≤ 110 | 4 | 0.78 (0.66-0.86) | 0.80 (0.71-0.87) | 3.91 (2.48-6.17) | 0.28 (0.17-0.45) | 0.86 (0.83-0.89) | 2.65 (1.76-3.53) | 14.12 (5.82-34.29) |
Serum | 6 | 0.87 (0.78–0.92) | 0.77 (0.60–0.88) | 3.72 (2.09–6.62) | 0.17 (0.11–0.28) | 0.90 (0.87–0.92) | 3.06 (2.22–3.90) | 21.37 (9.21–49.63) |
China | 6 | 0.78 (0.68–0.85) | 0.72 (0.62–0.81) | 2.82 (1.85–4.28) | 0.31 (0.19–0.49) | 0.82 (0.78–0.85) | 2.22 (1.35–3.08) | 9.17 (3.86–21.77) |
MSIS | 6 | 0.82 (0.74–0.88) | 0.78 (0.65–0.87) | 3.73 (2.14–6.49) | 0.23 (0.14–0.36) | 0.87 (0.84–0.90) | 2.78 (1.77–3.80) | 16.19 (5.86–44.70) |