Table 1 Description of included studies
Study | Country | Anesthesia | Surgical approach | No. of patients control group | No. of patients gabapentin group | Gabapentin intervention | Concomitant pain management |
|---|---|---|---|---|---|---|---|
Clarke (2009) | Canada | Spinal anesthesia | TKA | 7 | 7 | Gabapentin 600 mg 2 h preoperatively. | PCA with morphine |
8 | Gabapentin 600 mg 2 h preoperatively and 100 mg 3 times a day for 4 days postoperatively. | ||||||
7 | Gabapentin 600 mg 2 h preoperatively and 200 mg 3 times a day for 4 days postoperatively. | ||||||
7 | Gabapentin 600 mg 2 h preoperatively and 300 mg 3 times a day for 4 days postoperatively. | ||||||
Texas (2012) | America | Unclear | TKA | 17 | 20 | Gabapentin 600 mg preoperatively and 300 mg per 8 h for 3 days postoperatively. | Unclear |
Paul (2013) | Canada | Spinal anesthesia | TKA | 49 | 52 | Gabapentin 600 mg 2 h preoperatively and 200 mg 3 times a day for 2 days postoperatively. | PCA with morphine |
Clarke (2014) | Canada | Spinal anesthesia | TKA | 76 | 79 | Gabapentin 600 mg 2 h preoperatively and 200 mg 3 times a day for 4 days postoperatively. | PCA with morphine |
Lunn (2015) | Denmark | Spinal anesthesia | TKA | 99 | 100 | Gabapentin 900 mg 2 h preoperatively and 600 mg morning, 300 mg night for 7 days. | PCA with morphine |
99 | Gabapentin 1300 mg 2 h preoperatively and 900 mg morning,400 mg night for 7 days postoperatively. | ||||||
Clarke (2009) | Canada | Spinal anesthesia | THA | 39 | 40 | Gabapentin 600 mg 2 h preoperatively | PCA with morphine |
38 | Gabapentin 600 mg 2 h postoperatively | ||||||
Paul (2015) | Canada | Spinal anesthesia | THA | 54 | 48 | Gabapentin 600 mg 2 h preoperatively and 200 mg 3 times for 2 days postoperatively. | PCA with morphine |