Fig. 5
From: Atorvastatin promotes bone formation in aged apoE–/– mice through the Sirt1–Runx2 axis
Sirt1-Runx2 is mainly involved in atorvastatin-induced osteogenesis in BMSCs from apoE–/– mice. a The mRNA expression of Runx2, ALP, and OCN in the presence of 100 nmol/L atorvastatin with or without the treatment of EX527. b, c The protein expression of Runx2 in BMSCs from apoE–/– mice in the presence of 100 nmol/L atorvastatin with or without the treatment of EX527. N = 3. *p < 0.05, **p < 0.01 vs. control group. AT, atorvastatin