Fig. 1
From: Atorvastatin promotes bone formation in aged apoE–/– mice through the Sirt1–Runx2 axis
The effect of atorvastatin (10 mg/kg/day) treatment on bone volume in aged apoE−/− mice, as determined by micro-CT. a Representative 3D micro-CT images showing regions of the trabecular bone in the distal femurs. b The graphs represent measurements of bone mineral density (BMD), trabecular bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular spacing (Tb.Sp) in the femurs from control and atorvastatin groups. c Representative 3D micro-CT images showing regions of cortical bone in the femurs from control and atorvastatin groups. d The graphs represent measurements of BMD, total area (Tt.Ar), cortical area (Ct.Ar), cortical thickness (Ct.Th), and cortical porosity. N = 12 mice per group were examined. *p < 0.05, **p < 0.01, vs. control group