Evaluation of genetic susceptibility of common variants in SOX9 in patients with congenital talipes equinovarus in the Han Chinese population

Table 3 Genetic association between genetic polymorphisms of SOX9 and CTEV

CHR	SNP	POS	Genotypic analyses						Allelic Analyses
CHR	SNP	POS	Genotypes	Cases	Controls	OR[95% CI]	*χ²	P value	Alleles	Cases	Controls	OR[95% CI]	χ²	P value
			TT	0	0
17	rs144221941	72121913	CT	40	79	1.13[0.75–1.65]			T	40	79	1.11[0.75–1.63]
			CC	652	1434	ref	–	0.61	C	1344	2947	ref	0.28	0.60
			AA	165	356	1.03[0.80–1.33]
17	rs35126550	72122558	AG	346	753	1.03[0.83–1.27]			A	676	1465	1.02[0.90–1.16]
			GG	181	404	ref	0.08	0.96	G	708	1561	ref	0.07	0.79
			TT	0	0
17	rs2229989	72122794	CT	43	100	0.94[0.65–1.35]			T	43	100	0.94[0.65–1.35]
			CC	649	1413	ref	–	0.78	C	1341	2926	ref	0.12	0.73
			AA	0	0
17	rs145813713	72124722	AG	26	45	1.27[0.78–2.08]			A	26	45	1.27[0.78–2.06]
			GG	666	1468	ref	–	0.36	G	1358	2981	ref	0.92	0.34
			AA	40	81	1.07[0.71–1.60]
17	rs1042673	72125198	AG	248	536	1.03[0.85–1.24]			A	328	698	1.04[0.89–1.20]
			GG	404	896	ref	0.24	0.89	G	1056	2328	ref	0.21	0.64
			CC	9	24	0.82[0.38–1.77]
17	rs74999341	72125313	CT	155	339	1.00[0.80–1.24]			C	173	387	0.97[0.80–1.18]
			TT	528	1150	ref	0.26	0.88	T	1211	2639	ref	0.07	0.79
			CC	17	9	1.47[1.18–1.82]
17	rs73354570	72125316	AC	155	266	1.37[1.09–1.71]			C	189	284	1.53[1.26–1.86]
			AA	528	1238	ref	22.39	1.38 × 10⁻⁵	A	1195	2742	ref	18.09	2.11 × 10^-5

CHR chromosome, POS position
*Fisher exact tests were performed when sparse cells were presented. Threshold of P values was 0.05/7 ≈ 0.007. Significant results were highlighted in bold

ISSN: 1749-799X